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    Coq8a coenzyme Q8A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360887, updated on 9-Dec-2024

    Summary

    Official Symbol
    Coq8aprovided by RGD
    Official Full Name
    coenzyme Q8Aprovided by RGD
    Primary source
    RGD:1308245
    See related
    EnsemblRapid:ENSRNOG00000043201 AllianceGenome:RGD:1308245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adck3; Cabc1
    Summary
    Predicted to enable ADP binding activity and kinase activity. Predicted to be involved in phosphorylation and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 4. Orthologous to human COQ8A (coenzyme Q8A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2146.4), Liver (RPKM 1093.1) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Coq8a in Genome Data Viewer
    Location:
    13q26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (94436680..94465535, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91904731..91933588, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (98451629..98480438, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481630 Neighboring gene CDC42 binding protein kinase alpha Neighboring gene uncharacterized LOC102553289 Neighboring gene presenilin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Clone Names

    • MGC109473

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding  
    enables ADP binding  
    enables ATP binding  
    enables kinase activity  
    enables kinase activity  
    enables kinase activity  
    NOT enables protein kinase activity  
    NOT enables protein kinase activity  
    Process Evidence Code Pubs
    involved_in phosphorylation  
    involved_in phosphorylation  
    NOT involved_in protein phosphorylation  
    NOT involved_in protein phosphorylation  
    involved_in ubiquinone biosynthetic process  
    involved_in ubiquinone biosynthetic process  
    involved_in ubiquinone biosynthetic process  
    involved_in ubiquinone biosynthetic process  
    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    atypical kinase COQ8A, mitochondrial
    Names
    aarF domain containing kinase 3
    aarF domain-containing protein kinase 3
    atypical kinase ADCK3, mitochondrial
    chaperone activity of bc1 complex-like, mitochondrial
    chaperone, ABC1 activity of bc1 complex like
    coenzyme Q protein 8A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013185.1NP_001013203.1  atypical kinase COQ8A, mitochondrial

      See identical proteins and their annotated locations for NP_001013203.1

      Status: VALIDATED

      Source sequence(s)
      BC091388
      UniProtKB/Swiss-Prot
      Q5BJQ0
      UniProtKB/TrEMBL
      A0A8L2R303, A6JGG2
      Related
      ENSRNOP00000036948.4, ENSRNOT00000030135.6
      Conserved Domains (1) summary
      cd13970
      Location:296546
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    2. NM_001429620.1NP_001416549.1  atypical kinase COQ8A, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5BJQ0
      UniProtKB/TrEMBL
      A0A8L2R303, A6JGG2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      94436680..94465535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250387.2XP_006250449.1  atypical kinase COQ8A, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd13970
      Location:296546
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
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