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    Fam81a family with sequence similarity 81, member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam81aprovided by RGD
    Official Full Name
    family with sequence similarity 81, member Aprovided by RGD
    Primary source
    RGD:1311958
    See related
    EnsemblRapid:ENSRNOG00000057501 AllianceGenome:RGD:1311958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311958
    Summary
    Predicted to enable molecular condensate scaffold activity. Located in postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human FAM81A (family with sequence similarity 81 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 208.1), Kidney (RPKM 195.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam81a in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (79643754..79702792, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70762852..70821898, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (76521662..76579387, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene selenoprotein K, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480071

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FAM81A protein, a novel component of the postsynaptic density in adult brain. Dosemeci A, et al. Neurosci Lett, 2019 Apr 23. PMID 30735723, Free PMC Article
    2. FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. Kaizuka T, et al. PLoS Biol, 2024 Mar. PMID 38452102, Free PMC Article
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular condensate scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM81A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108163.2 → NP_001101633.1  protein FAM81A

      See identical proteins and their annotated locations for NP_001101633.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      A6KEU1, D4A7T8
      Related
      ENSRNOP00000071796.1, ENSRNOT00000090747.3
      Conserved Domains (1) summary
      COG1196
      Location:76 → 317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001433748.1 → NP_001420677.1  protein FAM81A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      A6KEU1, D4A7T8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      79643754..79702792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243379.5 → XP_006243441.1  protein FAM81A isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:76 → 317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006243378.5 → XP_006243440.1  protein FAM81A isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:76 → 317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A7T8.1 GenPept UniProtKB/Swiss-Prot:D4A7T8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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