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    Mtmr14 myotubularin related protein 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312634, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Mtmr14provided by RGD
    Official Full Name
    myotubularin related protein 14provided by RGD
    Primary source
    RGD:1304842
    See related
    EnsemblRapid:ENSRNOG00000007881 AllianceGenome:RGD:1304842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304842
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be located in perinuclear region of cytoplasm and ruffle. Human ortholog(s) of this gene implicated in centronuclear myopathy 1. Orthologous to human MTMR14 (myotubularin related protein 14). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 98.7), Liver (RPKM 79.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtmr14 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (147942604..147985649)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146386949..146429990)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145195046..145238097)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 4 Neighboring gene uncharacterized LOC134486623 Neighboring gene copine family member 9 Neighboring gene bromodomain and PHD finger containing, 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy. Tosch V, et al. Hum Mol Genet, 2006 Nov 1. PMID 17008356
    2. MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy. Pan Q, et al. Biochem Biophys Res Commun, 2020 Sep 3. PMID 32819563
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy.
      Title: MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin-related protein 14
    NP_001101350.1
    XP_006237086.1
    XP_006237087.1
    XP_006237088.1
    XP_038963556.1
    XP_038963558.1
    XP_038963560.1
    XP_038963561.1
    XP_063142155.1
    XP_063142156.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107880.1 → NP_001101350.1  myotubularin-related protein 14

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A0A8I5ZZY7, A6IBP6, D3ZMA2
      Related
      ENSRNOP00000010723.4, ENSRNOT00000010723.7
      Conserved Domains (1) summary
      cd13213
      Location:127 → 243
      PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      147942604..147985649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237024.5 → XP_006237086.1  myotubularin-related protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNW5, A0A8I5ZZY7
      Related
      ENSRNOP00000079859.1, ENSRNOT00000104597.2
      Conserved Domains (1) summary
      cd13213
      Location:127 → 243
      PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    2. XM_039107628.1 → XP_038963556.1  myotubularin-related protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZY7
      Related
      ENSRNOP00000094263.2, ENSRNOT00000114355.2
      Conserved Domains (2) summary
      cd13213
      Location:127 → 242
      PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cl28904
      Location:292 → 385
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_063286085.1 → XP_063142155.1  myotubularin-related protein 14 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZY7

    4. XM_063286086.1 → XP_063142156.1  myotubularin-related protein 14 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZZY7
      Related
      ENSRNOP00000112530.1, ENSRNOT00000151766.1

    5. XM_039107630.1 → XP_038963558.1  myotubularin-related protein 14 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZZY7
      Conserved Domains (2) summary
      cd13213
      Location:127 → 243
      PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cl28904
      Location:293 → 386
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_039107632.1 → XP_038963560.1  myotubularin-related protein 14 isoform X7

      Conserved Domains (2) summary
      cd13213
      Location:127 → 243
      PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cl28904
      Location:293 → 386
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    7. XM_006237026.4 → XP_006237088.1  myotubularin-related protein 14 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AL76
      Conserved Domains (1) summary
      cd13213
      Location:7 → 123
      PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    8. XM_006237025.4 → XP_006237087.1  myotubularin-related protein 14 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AL76
      Conserved Domains (1) summary
      cd13213
      Location:31 → 147
      PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    9. XM_039107633.1 → XP_038963561.1  myotubularin-related protein 14 isoform X9

      Conserved Domains (2) summary
      cl17171
      Location:38 → 59
      PH-like; Pleckstrin homology-like domain
      cl28904
      Location:109 → 202
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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