Kash5 KASH domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kash5provided by RGD
Official Full Name: KASH domain containing 5provided by RGD
Primary source: RGD:1561972
See related: EnsemblRapid:ENSRNOG00000025378 AllianceGenome:RGD:1561972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc155; RGD1561972; Ccdc155-ps1
Summary: Predicted to enable dynein complex binding activity and identical protein binding activity. Predicted to be involved in several processes, including cytoskeleton organization; homologous chromosome segregation; and spindle localization. Predicted to act upstream of or within several processes, including double-strand break repair via homologous recombination; meiotic telomere clustering; and spermatogenesis. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in chromosome; meiotic spindle pole; and nuclear outer membrane. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 88. Orthologous to human KASH5 (KASH domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 72.3), Muscle (RPKM 17.5) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104805248..104827720, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95668918..95691353, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101180497..101203048, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in chromosome localization to nuclear envelope involved in homologous chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chromosome localization to nuclear envelope involved in homologous chromosome segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome pairing at meiosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic telomere clustering	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in spindle localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle localization	ISO Inferred from Sequence Orthology more info
involved_in telomere localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in lateral element	IBA Inferred from Biological aspect of Ancestor more info
located_in lateral element	ISO Inferred from Sequence Orthology more info
part_of meiotic nuclear membrane microtubule tethering complex	IBA Inferred from Biological aspect of Ancestor more info
part_of meiotic nuclear membrane microtubule tethering complex	ISO Inferred from Sequence Orthology more info
is_active_in meiotic spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in meiotic spindle pole	ISO Inferred from Sequence Orthology more info
is_active_in nuclear outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: KASH domain containing 5; protein KASH5

Names: coiled-coil domain containing 155, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432239.1 → NP_001419168.1 KASH domain containing 5 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D3ZPX3
NM_001432240.1 → NP_001419169.1 KASH domain containing 5 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001432241.1 → NP_001419170.1 KASH domain containing 5 isoform c

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001432242.1 → NP_001419171.1 KASH domain containing 5 isoform d

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001432243.1 → NP_001419172.1 KASH domain containing 5 isoform e

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001432245.1 → NP_001419174.1 KASH domain containing 5 isoform e

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001432246.1 → NP_001419175.1 KASH domain containing 5 isoform f

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001432247.1 → NP_001419176.1 KASH domain containing 5 isoform f

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104805248..104827720 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278194.1 → XP_063134264.1 protein KASH5 isoform X2
XM_063278191.1 → XP_063134261.1 protein KASH5 isoform X1
XM_063278201.1 → XP_063134271.1 protein KASH5 isoform X4
XM_063278198.1 → XP_063134268.1 protein KASH5 isoform X3
XM_063278223.1 → XP_063134293.1 protein KASH5 isoform X8
XM_063278212.1 → XP_063134282.1 protein KASH5 isoform X7
XM_039094057.2 → XP_038949985.1 protein KASH5 isoform X6

Related

ENSRNOP00000037916.8, ENSRNOT00000037998.8

Conserved Domains (2) summary

pfam14658
Location:78 → 145

EF-hand_9; EF-hand domain

pfam14662
Location:213 → 367

KASH_CCD; Coiled-coil region of CCDC155 or KASH
XM_006229199.5 → XP_006229261.1 protein KASH5 isoform X5

Related

ENSRNOP00000101435.1, ENSRNOT00000138492.1

Conserved Domains (4) summary

pfam14658
Location:78 → 145

EF-hand_9; EF-hand domain

pfam14662
Location:197 → 388

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam16046
Location:237 → 313

FAM76; FAM76 protein

cl12013
Location:223 → 385

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature