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    Mettl1 methyltransferase 1, tRNA methylguanosine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mettl1provided by RGD
    Official Full Name
    methyltransferase 1, tRNA methylguanosineprovided by RGD
    Primary source
    RGD:1593036
    See related
    EnsemblRapid:ENSRNOG00000047895 AllianceGenome:RGD:1593036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable internal mRNA (guanine-N7-)-methyltransferase activity and tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in tRNA (guanine-N7)-methylation and tRNA stabilization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 39.1), Kidney (RPKM 33.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64750189..64754531)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62864860..62869202)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70328470..70333045)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane associated ring-CH-type finger 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. Cartlidge RA, et al. EMBO J, 2005 May 4. PMID 15861136, Free PMC Article
    2. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. Alexandrov A, et al. RNA, 2002 Oct. PMID 12403464, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables internal mRNA (guanine-N7-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA (guanine-N7)-methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA (guanine-N7)-methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of tRNA (m7G46) methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of tRNA methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine-N(7)-)-methyltransferase
    Names
    methyltransferase like 1
    NP_001385862.1
    NP_001385863.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398933.1 → NP_001385862.1  tRNA (guanine-N(7)-)-methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HQR6, M0R637
      Related
      ENSRNOP00000064874.3, ENSRNOT00000075544.4
      Conserved Domains (1) summary
      pfam02390
      Location:70 → 247
      Methyltransf_4; Putative methyltransferase

    2. NM_001398934.1 → NP_001385863.1  tRNA (guanine-N(7)-)-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AXQ2
      Related
      ENSRNOP00000093899.1, ENSRNOT00000117922.2
      Conserved Domains (1) summary
      pfam02390
      Location:34 → 211
      Methyltransf_4; Putative methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64750189..64754531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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