Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Zfp91 zinc finger protein 91 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246282, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Zfp91provided by RGD
    Official Full Name
    zinc finger protein 91provided by RGD
    Primary source
    RGD:628736
    See related
    EnsemblRapid:ENSRNOG00000012524 AllianceGenome:RGD:628736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in activation of NF-kappaB-inducing kinase activity; protein K63-linked ubiquitination; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Used to study acute myeloid leukemia. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 406.5), Heart (RPKM 360.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Zfp91 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (219316002..219353654, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209891344..209928890, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (229602499..229640906, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycine-N-acyltransferase-like 2 Neighboring gene ciliary neurotrophic factor Neighboring gene leupaxin Neighboring gene small nucleolar RNA U13 Neighboring gene olfactory receptor family 5 subfamily B member 21

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Multiplex differential display identifies a novel zinc-finger protein repressed during withdrawal from cocaine. Ennulat DJ, et al. Brain Res Mol Brain Res, 1997 Oct 3. PMID 9387892
    2. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. Jin X, et al. J Biol Chem, 2010 Oct 1. PMID 20682767, Free PMC Article
    3. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Unoki M, et al. Int J Oncol, 2003 Jun. PMID 12738986
    4. The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization. Tang DE, et al. Carcinogenesis, 2020 Mar 13. PMID 31046116
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of NF-kappaB-inducing kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin-protein ligase ZFP91
    Names
    cocaine attenuated zinc-finger protein
    NP_001162591.1
    XP_006231189.1
    XP_063137076.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169120.1 → NP_001162591.1  E3 ubiquitin-protein ligase ZFP91

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AEZ3, F1MAJ8
      Related
      ENSRNOP00000016804.5, ENSRNOT00000016804.8
      Conserved Domains (3) summary
      sd00017
      Location:345 → 364
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:384 → 409
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:311 → 388
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      219316002..219353654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231127.5 → XP_006231189.1  E3 ubiquitin-protein ligase ZFP91 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:236 → 255
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:275 → 300
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:202 → 279
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_063281006.1 → XP_063137076.1  E3 ubiquitin-protein ligase ZFP91 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEZ3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools