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    Shld1 shieldin complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681292, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shld1provided by RGD
    Official Full Name
    shieldin complex subunit 1provided by RGD
    Primary source
    RGD:1597982
    See related
    EnsemblRapid:ENSRNOG00000021268 AllianceGenome:RGD:1597982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in chromosome. Predicted to be active in site of double-strand break. Orthologous to human SHLD1 (shieldin complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 18.7), Lung (RPKM 16.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Shld1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140391611..140462273)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (119938695..120011068)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125318682..125396705)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101670 Neighboring gene glycerophosphocholine phosphodiesterase 1 Neighboring gene uncharacterized LOC102552951 Neighboring gene U6 spliceosomal RNA Neighboring gene chromogranin B Neighboring gene tRNA methyltransferase 6 non-catalytic subunit

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    shieldin complex subunit 1
    Names
    uncharacterized protein C20orf196 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399552.1NP_001386481.1  shieldin complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A0G4, A0A8I6AUR4, A6HQH1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      140391611..140462273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106576.2XP_038962504.1  shieldin complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AUR4
      Related
      ENSRNOP00000028891.6, ENSRNOT00000028891.8
      Conserved Domains (1) summary
      pfam15021
      Location:4226
      DUF4521; Protein of unknown function (DUF4521)
    2. XM_008762239.4XP_008760461.1  shieldin complex subunit 1 isoform X4

      See identical proteins and their annotated locations for XP_008760461.1

      UniProtKB/TrEMBL
      A0A8I6AUR4, D3ZVK4
      Related
      ENSRNOP00000108399.1, ENSRNOT00000140888.1
      Conserved Domains (1) summary
      pfam15021
      Location:5205
      DUF4521; Protein of unknown function (DUF4521)
    3. XM_063284550.1XP_063140620.1  shieldin complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AUR4
    4. XM_063284549.1XP_063140619.1  shieldin complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYL2
    5. XM_063284551.1XP_063140621.1  shieldin complex subunit 1 isoform X5