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    Ano8 anoctamin 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306340, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ano8provided by RGD
    Official Full Name
    anoctamin 8provided by RGD
    Primary source
    RGD:1563946
    See related
    EnsemblRapid:ENSRNOG00000058662 AllianceGenome:RGD:1563946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563946
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human ANO8 (anoctamin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 74.2), Brain (RPKM 71.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ano8 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18197829..18207205, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18163853..18173248, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19884661..19894608, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 8 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene GTP binding protein 3 Neighboring gene uncharacterized LOC134482466 Neighboring gene plasmalemma vesicle associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CFTR and TMEM16A are separate but functionally related Cl- channels. Ousingsawat J, et al. Cell Physiol Biochem, 2011. PMID 22178883
    2. Expression and function of epithelial anoctamins. Schreiber R, et al. J Biol Chem, 2010 Mar 5. PMID 20056604, Free PMC Article
    3. Anoctamins are a family of Ca2+-activated Cl- channels. Tian Y, et al. J Cell Sci, 2012 Nov 1. PMID 22946059
    4. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Scudieri P, et al. Exp Physiol, 2012 Feb. PMID 21984732
    5. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables phospholipid scramblase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anoctamin-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427623.1 → NP_001414552.1  anoctamin-8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6A8H8, A0A8I6AJK6
      Related
      ENSRNOP00000085290.1, ENSRNOT00000111787.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18197829..18207205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095002.2 → XP_038950930.1  anoctamin-8 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GCQ3
      Related
      ENSRNOP00000094433.2, ENSRNOT00000093953.2
      Conserved Domains (2) summary
      PRK12323
      Location:908 → 1086
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:184 → 860
      Anoctamin; Calcium-activated chloride channel

    2. XM_039094999.2 → XP_038950927.1  anoctamin-8 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GCQ3
      Conserved Domains (2) summary
      PRK12323
      Location:922 → 1100
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:198 → 874
      Anoctamin; Calcium-activated chloride channel

    3. XM_039094998.2 → XP_038950926.1  anoctamin-8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GCQ3
      Conserved Domains (2) summary
      PRK12323
      Location:945 → 1123
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:221 → 897
      Anoctamin; Calcium-activated chloride channel

    4. XM_039095003.2 → XP_038950931.1  anoctamin-8 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GCQ3
      Conserved Domains (2) summary
      PRK12323
      Location:892 → 1070
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:237 → 844
      Anoctamin; Calcium-activated chloride channel

    5. XM_039094997.2 → XP_038950925.1  anoctamin-8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GCQ3
      Conserved Domains (2) summary
      PRK12323
      Location:961 → 1139
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:237 → 913
      Anoctamin; Calcium-activated chloride channel

    6. XM_039095000.2 → XP_038950928.1  anoctamin-8 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K5K1, A0A8I6A8H8
      Related
      ENSRNOP00000073456.2, ENSRNOT00000085940.3
      Conserved Domains (2) summary
      PRK12323
      Location:917 → 1095
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:237 → 869
      Anoctamin; Calcium-activated chloride channel
    Nucleotide Protein Strain
    Heading Accession and Version

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