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    B4galt6 beta-1,4-galactosyltransferase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65196, updated on 9-Dec-2024

    Summary

    Official Symbol
    B4galt6provided by RGD
    Official Full Name
    beta-1,4-galactosyltransferase 6provided by RGD
    Primary source
    RGD:71046
    See related
    EnsemblRapid:ENSRNOG00000015895 AllianceGenome:RGD:71046
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 145.5), Lung (RPKM 121.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See B4galt6 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (12233350..12290204, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (11958382..12015247, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (15462913..15525584)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551809 Neighboring gene transthyretin Neighboring gene uncharacterized LOC102551486 Neighboring gene importin 5, pseudogene 1 Neighboring gene uncharacterized LOC120098272

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process  
    involved_in central nervous system myelination  
    involved_in central nervous system myelination  
    involved_in central nervous system neuron axonogenesis  
    involved_in central nervous system neuron axonogenesis  
    involved_in ganglioside biosynthetic process via lactosylceramide  
    involved_in ganglioside biosynthetic process via lactosylceramide  
    involved_in glycosphingolipid biosynthetic process  
    involved_in glycosphingolipid biosynthetic process PubMed 
    involved_in glycosylation  
    involved_in lactosylceramide biosynthetic process  
    involved_in neuron maturation  
    involved_in neuron maturation  
    involved_in protein glycosylation  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi cisterna membrane  
    located_in Golgi membrane  

    General protein information

    Preferred Names
    beta-1,4-galactosyltransferase 6
    Names
    LacCer synthase
    Lactosylceramide Synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
    UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6
    b4Gal-T6
    beta-1,4-GalTase 6
    beta4Gal-T6
    glucosylceramide beta-1,4-galactosyltransferase
    NP_113928.1
    XP_038953013.1
    XP_038953015.1
    XP_038953016.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031740.3NP_113928.1  beta-1,4-galactosyltransferase 6

      See identical proteins and their annotated locations for NP_113928.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      O88419
      UniProtKB/TrEMBL
      A6J2G4
      Related
      ENSRNOP00000082568.1, ENSRNOT00000111678.2
      Conserved Domains (1) summary
      cd00899
      Location:155371
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      12233350..12290204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097085.2XP_038953013.1  beta-1,4-galactosyltransferase 6 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MXX9
      Conserved Domains (1) summary
      cd00899
      Location:130346
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    2. XM_039097087.2XP_038953015.1  beta-1,4-galactosyltransferase 6 isoform X2

      Conserved Domains (1) summary
      cd00899
      Location:111327
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    3. XM_039097088.2XP_038953016.1  beta-1,4-galactosyltransferase 6 isoform X2

      Related
      ENSRNOP00000021764.8, ENSRNOT00000021764.9
      Conserved Domains (1) summary
      cd00899
      Location:111327
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
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