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    Zng1a Zn regulated GTPase metalloprotein activator 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zng1aprovided by RGD
    Official Full Name
    Zn regulated GTPase metalloprotein activator 1Aprovided by RGD
    Primary source
    RGD:708495
    See related
    EnsemblRapid:ENSRNOG00000015516 AllianceGenome:RGD:708495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zng1; Cbwd1
    Summary
    Predicted to enable GTPase activity and zinc chaperone activity. Predicted to be involved in intracellular zinc ion homeostasis; kidney development; and protein maturation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to several human genes including ZNG1A (Zn regulated GTPase metalloprotein activator 1A); ZNG1C (Zn regulated GTPase metalloprotein activator 1C); and ZNG1E (Zn regulated GTPase metalloprotein activator 1E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 64.5), Thymus (RPKM 44.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zng1a in Genome Data Viewer
    Location:
    1q51
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (231994651..232039314, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (222568278..222612937, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (242819383..242861792, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 5 Neighboring gene forkhead box D4 Neighboring gene uncharacterized LOC102556915 Neighboring gene uncharacterized LOC134483982 Neighboring gene uncharacterized LOC134483983 Neighboring gene dedicator of cytokinesis 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. Shi J, et al. Brain Res, 2001 Aug 10. PMID 11489251
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc chaperone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc-regulated GTPase metalloprotein activator 1
    Names
    COBW domain containing 1
    COBW domain-containing protein 1
    cobalamin synthase W domain-containing protein 1
    cobalamin synthetase W domain-containing protein 1
    dopamine responsive protein
    NP_598219.2
    XP_006231253.1
    XP_006231254.1
    XP_006231255.1
    XP_038942019.1
    XP_063129656.1
    XP_063129697.1
    XP_063129786.1
    XP_063129815.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133535.2 → NP_598219.2  zinc-regulated GTPase metalloprotein activator 1

      Status: PROVISIONAL

      Source sequence(s)
      BC086376
      UniProtKB/Swiss-Prot
      Q5RK12, Q99MB4
      UniProtKB/TrEMBL
      A0A8I6GGE7
      Related
      ENSRNOP00000081860.1, ENSRNOT00000108052.2
      Conserved Domains (3) summary
      COG0523
      Location:41 → 377
      YejR; GTPase, G3E family [General function prediction only]
      pfam07683
      Location:272 → 371
      CobW_C; Cobalamin synthesis protein cobW C-terminal domain
      cl21455
      Location:42 → 206
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      231994651..232039314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086091.2 → XP_038942019.1  zinc-regulated GTPase metalloprotein activator 1 isoform X8

      Conserved Domains (1) summary
      COG0523
      Location:1 → 255
      YejR; GTPase, G3E family [General function prediction only]

    2. XM_006231193.5 → XP_006231255.1  zinc-regulated GTPase metalloprotein activator 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GGE7
      Conserved Domains (3) summary
      COG0523
      Location:41 → 320
      YejR; GTPase, G3E family [General function prediction only]
      pfam07683
      Location:254 → 314
      CobW_C; Cobalamin synthesis protein cobW C-terminal domain
      cl21455
      Location:42 → 206
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_063273716.1 → XP_063129786.1  zinc-regulated GTPase metalloprotein activator 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GGE7

    4. XM_006231192.5 → XP_006231254.1  zinc-regulated GTPase metalloprotein activator 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AN13, A0A8I6GGE7
      Related
      ENSRNOP00000097012.2, ENSRNOT00000104262.2
      Conserved Domains (3) summary
      COG0523
      Location:41 → 343
      YejR; GTPase, G3E family [General function prediction only]
      pfam07683
      Location:238 → 337
      CobW_C; Cobalamin synthesis protein cobW C-terminal domain
      cl21455
      Location:42 → 206
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_063273627.1 → XP_063129697.1  zinc-regulated GTPase metalloprotein activator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GGE7
      Related
      ENSRNOP00000099850.1, ENSRNOT00000153445.1

    6. XM_006231191.5 → XP_006231253.1  zinc-regulated GTPase metalloprotein activator 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A519, A0A8I6GGE7
      Related
      ENSRNOP00000087771.2, ENSRNOT00000105156.2
      Conserved Domains (3) summary
      COG0523
      Location:41 → 354
      YejR; GTPase, G3E family [General function prediction only]
      pfam07683
      Location:288 → 348
      CobW_C; Cobalamin synthesis protein cobW C-terminal domain
      cl21455
      Location:42 → 206
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    7. XM_063273586.1 → XP_063129656.1  zinc-regulated GTPase metalloprotein activator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GGE7, A6I0R1
      Related
      ENSRNOP00000021185.4, ENSRNOT00000021185.9

    8. XM_063273745.1 → XP_063129815.1  zinc-regulated GTPase metalloprotein activator 1 isoform X7

      UniProtKB/TrEMBL
      A6I0R2

    RNA

    1. XR_010057544.1 RNA Sequence

    2. XR_010057529.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MB4.2 GenPept UniProtKB/Swiss-Prot:Q99MB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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