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    Capg capping actin protein, gelsolin like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Capgprovided by RGD
    Official Full Name
    capping actin protein, gelsolin likeprovided by RGD
    Primary source
    RGD:1311724
    See related
    EnsemblRapid:ENSRNOG00000013668 AllianceGenome:RGD:1311724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in several cellular components, including Flemming body; microtubule cytoskeleton; and nuclear lumen. Predicted to be active in actin cytoskeleton and cytoplasm. Orthologous to human CAPG (capping actin protein, gelsolin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 175.4), Lung (RPKM 112.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Capg in Genome Data Viewer
    Location:
    4q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (106152912..106170010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104594743..104611856)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100395693..100419447)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene SH2 domain containing 6 Neighboring gene transfer RNA proline (anticodon AGG) 74 Neighboring gene ELMO domain containing 3 Neighboring gene retinol saturase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The F-actin filament capping protein CapG is a bona fide nucleolar protein. Hubert T, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18938132
    2. Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. Witke W, et al. J Cell Biol, 2001 Aug 20. PMID 11514591, Free PMC Article
    3. The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Hubert T, et al. Biochem Biophys Res Commun, 2009 Feb 27. PMID 19166812
    4. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. Van Impe K, et al. Traffic, 2008 May. PMID 18266911
    5. L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages. De Clercq S, et al. PLoS One, 2013. PMID 24236012, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    macrophage-capping protein
    Names
    actin regulatory protein CAP-G
    capping protein (actin filament), gelsolin-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013086.1 → NP_001013104.1  macrophage-capping protein

      See identical proteins and their annotated locations for NP_001013104.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079104
      UniProtKB/Swiss-Prot
      Q6AYC4
      UniProtKB/TrEMBL
      A0A8I6A6Z2, A6IAC6
      Conserved Domains (3) summary
      cd11289
      Location:139 → 226
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 347
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      106152912..106170010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236661.5 → XP_006236723.1  macrophage-capping protein isoform X2

      See identical proteins and their annotated locations for XP_006236723.1

      UniProtKB/Swiss-Prot
      Q6AYC4
      UniProtKB/TrEMBL
      A0A8I6A6Z2, A6IAC6
      Related
      ENSRNOP00000087979.1, ENSRNOT00000108841.2
      Conserved Domains (3) summary
      cd11289
      Location:139 → 226
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 347
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

    2. XM_006236663.5 → XP_006236725.1  macrophage-capping protein isoform X2

      See identical proteins and their annotated locations for XP_006236725.1

      UniProtKB/Swiss-Prot
      Q6AYC4
      UniProtKB/TrEMBL
      A0A8I6A6Z2, A6IAC6
      Conserved Domains (3) summary
      cd11289
      Location:139 → 226
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 347
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

    3. XM_039107321.2 → XP_038963249.1  macrophage-capping protein isoform X2

      UniProtKB/Swiss-Prot
      Q6AYC4
      UniProtKB/TrEMBL
      A0A8I6A6Z2, A6IAC6
      Conserved Domains (3) summary
      cd11289
      Location:139 → 226
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 347
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

    4. XM_039107320.2 → XP_038963248.2  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6Z2, A0A8L2Q9I9
      Related
      ENSRNOP00000018562.4, ENSRNOT00000018562.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYC4.1 GenPept UniProtKB/Swiss-Prot:Q6AYC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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