Pmel premelanosome protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pmelprovided by RGD
Official Full Name: premelanosome proteinprovided by RGD
Primary source: RGD:1307513
See related: EnsemblRapid:ENSRNOG00000023085 AllianceGenome:RGD:1307513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Silv
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in melanosome organization and positive regulation of melanin biosynthetic process. Predicted to act upstream of or within melanin biosynthetic process. Predicted to be located in several cellular components, including cis-Golgi network membrane; cytoplasmic vesicle; and extracellular exosome. Predicted to be active in melanosome and plasma membrane. Orthologous to human PMEL (premelanosome protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 19.0), Thymus (RPKM 13.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1721948..1733248)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (1138202..1148735)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (3133347..3143827)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.
Title: TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127677 (e-PCR)
- UniSTS:210987

RH133773 (e-PCR)
- UniSTS:217056

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body, internal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanocyte protein PMEL

Names: melanocyte protein Pmel 17; silver homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427188.1 → NP_001414117.1 melanocyte protein PMEL precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

D3ZED8

Related

ENSRNOP00000048469.3, ENSRNOT00000049972.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1721948..1733248

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263712.1 → XP_063119782.1 melanocyte protein PMEL isoform X2
XM_039080007.2 → XP_038935935.1 melanocyte protein PMEL isoform X1

UniProtKB/TrEMBL

A0A8I5ZTD1, D3ZED8

Related

ENSRNOP00000082328.1, ENSRNOT00000112501.2

Conserved Domains (2) summary

pfam05109
Location:295 → 417

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam00801
Location:223 → 289

PKD; PKD domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108729.1: Suppressed sequence

Description

NM_001108729.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: pmela (GeneID:321239).