Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts4provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 4provided by RGD
Primary source: RGD:621242
See related: EnsemblRapid:ENSRNOG00000003538 AllianceGenome:RGD:621242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metalloendopeptidase activity; protease binding activity; and zinc ion binding activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular space and nuclear speck. Predicted to be active in extracellular matrix. Biomarker of degenerative disc disease and transient cerebral ischemia. Orthologous to human ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 40.7), Uterus (RPKM 12.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86203011..86212500)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83670556..83680045)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89622996..89632485)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1-4-8 during the three trimesters of rat pregnancy at the maternal-fetal interface.
Title: Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1-4-8 during the three trimesters of rat pregnancy at the maternal-fetal interface.
ADAMTS4 mRNA increased at 3 h after myocardial infarction, peaked at 6 h, then decreased rapidly; protein levels of ADAMTS4 were significantly increased at 6 h, 12 h, 24 h and 3 d after MI.
Title: The quantification of ADAMTS4 and 8 expression and selection of reference genes for quantitative real-time PCR analysis in myocardial infarction.
Inhibition of aggrecanase-1 decreases aggrecan degradation in cultured rat chondrocytes.
Title: [Effects of RNA interference against aggrecanase 1 gene on extracellular matrix metabolism of cultured chondrocytes in vitro].
Together these data demonstrate that inhibition of endogenous aggrecanases facilitates chondrocyte differentiation and chondrocyte-engineered cartilage formation in vitro.
Title: Lentivirus-mediated knockdown of aggrecanase-1 and -2 promotes chondrocyte-engineered cartilage formation in vitro.
This study suggests that dental pulp cells, odontoblasts, cementoblasts, cementocytes, periodontal ligament cells, osteoblasts and osteocytes may be involved in both production and degradation of versican with secreting ADAMTS1, ADAMTS4 and ADAMTS5.
Title: Expression of versican and ADAMTS during rat tooth eruption.
ADAMTS-5 mainly contributed to ECM metabolism in growth plate and condylar cartilage during growth. ADAMTS-1 and ADAMTS-4 may be involved in ECM turn over in articular cartilage.
Title: Comparison of age-dependent expression of aggrecan and ADAMTSs in mandibular condylar cartilage, tibial growth plate, and articular cartilage in rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 4

Names: ADAM-TS 4; ADAM-TS4; ADAMTS-4; Aggrecanase; a disintegrin and metallopeptidase with thrombospondin motifs 4; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; aggrecanase-1

NP_076449.1

EC 3.4.24.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023959.1 → NP_076449.1 A disintegrin and metalloproteinase with thrombospondin motifs 4

Status: VALIDATED

Source sequence(s)

AB042271, AB042272, AB042273, CB614460, JAXUCZ010000013

UniProtKB/TrEMBL

D4A0C5

Related

ENSRNOP00000004713.6, ENSRNOT00000004713.9

Conserved Domains (6) summary

smart00209
Location:545 → 589

TSP1; Thrombospondin type 1 repeats

cd04273
Location:232 → 439

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:232 → 442

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:92 → 195

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:701 → 816

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:452 → 523

ADAM_CR; ADAM cysteine-rich