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    Frmpd2 FERM and PDZ domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498583, updated on 9-Dec-2024

    Summary

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    Symbol
    Frmpd2provided by RGD
    Full Name
    FERM and PDZ domain containing 2provided by RGD
    Primary source
    RGD:1565652
    See related
    EnsemblRapid:ENSRNOG00000029131 AllianceGenome:RGD:1565652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565652; AABR07024637.1
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity. Predicted to be involved in bicellular tight junction assembly. Predicted to be located in basolateral plasma membrane and bicellular tight junction. Orthologous to human FRMPD2 (FERM and PDZ domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 19.7), Kidney (RPKM 7.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frmpd2 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (8763889..8883558)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (8757642..8877307)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (9745171..9879490)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 22 Neighboring gene uncharacterized LOC134482457 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene protein tyrosine phosphatase, non-receptor type 20 Neighboring gene uncharacterized LOC108348435

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. Stenzel N, et al. J Cell Sci, 2009 Sep 15. PMID 19706687
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM and PDZ domain containing 2; FERM and PDZ domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432848.1 → NP_001419777.1  FERM and PDZ domain containing 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      F1LVM9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      8763889..8883558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094910.2 → XP_038950838.1  FERM and PDZ domain-containing protein 2 isoform X1

      Related
      ENSRNOP00000048385.6, ENSRNOT00000048001.7
      Conserved Domains (6) summary
      smart00228
      Location:922 → 1010
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:343 → 549
      B41; Band 4.1 homologues
      cd00992
      Location:768 → 852
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:545 → 645
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:15 → 197
      PKc_like; Protein Kinases, catalytic domain
      cl28922
      Location:340 → 433
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_039094911.2 → XP_038950839.1  FERM and PDZ domain-containing protein 2 isoform X2

      Conserved Domains (6) summary
      smart00228
      Location:922 → 1010
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:343 → 549
      B41; Band 4.1 homologues
      cd00992
      Location:768 → 852
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:545 → 645
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:15 → 197
      PKc_like; Protein Kinases, catalytic domain
      cl28922
      Location:340 → 433
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_039094912.2 → XP_038950840.1  FERM and PDZ domain-containing protein 2 isoform X3

      Conserved Domains (3) summary
      smart00228
      Location:361 → 449
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:207 → 291
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:1 → 84
      PH-like; Pleckstrin homology-like domain

    4. XM_063275920.1 → XP_063131990.1  FERM and PDZ domain-containing protein 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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