Apcs amyloid P component, serum [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apcsprovided by RGD
Official Full Name: amyloid P component, serumprovided by RGD
Primary source: RGD:68322
See related: EnsemblRapid:ENSRNOG00000009086 AllianceGenome:RGD:68322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sap
Summary: Predicted to enable several functions, including complement component C1q complex binding activity; identical protein binding activity; and virion binding activity. Involved in protein-containing complex assembly. Part of protein-containing complex. Human ortholog(s) of this gene implicated in amyloidosis. Orthologous to human APCS (amyloid P component, serum). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 5583.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (87905532..87906508, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (85373219..85374195, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (91426621..91427417, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum Amyloid P-Component plays an important role in the pathomechanism of neurodegenerative diseases, including Alzheimer's disease by inducing neuronal apoptosis.
Title: Serum amyloid P component induces neuronal apoptosis and beta-amyloid immunoreactivity.
Glycosaminoglycans interfere with the binding site on beta-amyloid for serum amyloid P component and C1q, and might have therapeutical potential on neurodegeneration
Title: Glycosaminoglycans inhibit neurodegenerative effects of serum amyloid P component in vitro.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables complement component C1q complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C1q complex binding	IEA Inferred from Electronic Annotation more info
enables complement component C1q complex binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables virion binding	IEA Inferred from Electronic Annotation more info
enables virion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral exo-alpha-sialidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of viral glycoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of exo-alpha-sialidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral process	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serum amyloid P-component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.