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    Ptger4 prostaglandin E receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84023, updated on 27-Dec-2024

    Summary

    Official Symbol
    Ptger4provided by RGD
    Official Full Name
    prostaglandin E receptor 4provided by RGD
    Primary source
    RGD:628641
    See related
    EnsemblRapid:ENSRNOG00000013240 AllianceGenome:RGD:628641
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EP4; Ptger; Ptgerep4
    Summary
    Enables prostaglandin E receptor activity. Involved in several processes, including intracellular signaling cassette; regulation of cytokine production; and regulation of secretion. Located in neuron projection terminus; neuronal cell body; and nuclear membrane. Used to study acute kidney failure; cystitis; end stage renal disease; myocarditis; and osteoporosis. Biomarker of retinal ischemia and transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 55.1), Spleen (RPKM 41.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ptger4 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (56061699..56074594, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (54330563..54347451, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54951625..54966470, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 5 Neighboring gene uncharacterized LOC120100730 Neighboring gene uncharacterized LOC103691475 Neighboring gene ribosomal protein S15A-like 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity  
    enables prostaglandin E receptor activity PubMed 
    enables prostaglandin E receptor activity  
    enables prostaglandin E receptor activity  
    enables prostaglandin E receptor activity  
    Items 1 - 25 of 102
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade PubMed 
    involved_in JNK cascade PubMed 
    involved_in T-helper cell differentiation  
    involved_in T-helper cell differentiation  
    involved_in T-helper cell differentiation  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
    involved_in bone development PubMed 
    involved_in cAMP biosynthetic process PubMed 
    involved_in cAMP/PKA signal transduction PubMed 
    involved_in cellular response to glucose stimulus PubMed 
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to prostaglandin E stimulus  
    involved_in cellular response to prostaglandin E stimulus PubMed 
    involved_in cellular response to prostaglandin E stimulus PubMed 
    involved_in chemokinesis PubMed 
    involved_in ductus arteriosus closure PubMed 
    involved_in female pregnancy PubMed 
    involved_in immune response  
    involved_in inflammatory response  
    involved_in maternal process involved in parturition PubMed 
    involved_in negative regulation of cytokine production  
    involved_in negative regulation of cytokine production  
    involved_in negative regulation of cytokine production  
    involved_in negative regulation of ductus arteriosus closure PubMed 
    involved_in negative regulation of endothelin production PubMed 
    involved_in negative regulation of eosinophil extravasation  
    involved_in negative regulation of eosinophil extravasation  
    involved_in negative regulation of eosinophil extravasation  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of inflammatory response  
    acts_upstream_of_or_within negative regulation of inflammatory response  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of integrin activation  
    involved_in negative regulation of integrin activation  
    involved_in negative regulation of integrin activation  
    involved_in negative regulation of interleukin-1 alpha production PubMed 
    involved_in negative regulation of peptide secretion PubMed 
    involved_in negative regulation of small intestine smooth muscle contraction PubMed 
    involved_in negative regulation of tumor necrosis factor production PubMed 
    involved_in positive regulation of antral ovarian follicle growth PubMed 
    involved_in positive regulation of bone resorption PubMed 
    involved_in positive regulation of calcitonin secretion PubMed 
    involved_in positive regulation of cell adhesion PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of chemokinesis PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep PubMed 
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of hyaluronan biosynthetic process PubMed 
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of interleukin-10 production PubMed 
    involved_in positive regulation of interleukin-8 production PubMed 
    involved_in positive regulation of matrix metallopeptidase secretion PubMed 
    involved_in positive regulation of mucus secretion PubMed 
    involved_in positive regulation of mucus secretion PubMed 
    involved_in positive regulation of neutrophil extravasation PubMed 
    involved_in positive regulation of ossification PubMed 
    involved_in positive regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of ovarian follicle development PubMed 
    involved_in positive regulation of protein modification process PubMed 
    involved_in positive regulation of protein secretion PubMed 
    involved_in positive regulation of smooth muscle cell migration PubMed 
    involved_in positive regulation of substance P secretion PubMed 
    involved_in positive regulation of substance P secretion, neurotransmission PubMed 
    involved_in positive regulation of urine volume PubMed 
    involved_in positive regulation of wound healing PubMed 
    involved_in regulation of circadian sleep/wake cycle, wakefulness PubMed 
    involved_in regulation of ossification  
    acts_upstream_of_or_within regulation of ossification  
    involved_in regulation of stress fiber assembly  
    involved_in regulation of stress fiber assembly  
    involved_in regulation of stress fiber assembly  
    involved_in response to amino acid PubMed 
    involved_in response to interleukin-1 PubMed 
    involved_in response to lipopolysaccharide  
    acts_upstream_of_or_within response to lipopolysaccharide  
    involved_in response to mechanical stimulus  
    involved_in response to nematode  
    acts_upstream_of_or_within response to nematode  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to progesterone PubMed 
    involved_in response to prostaglandin E  
    involved_in response to prostaglandin E PubMed 
    involved_in response to prostaglandin E  
    involved_in response to salt PubMed 
    involved_in response to water-immersion restraint stress PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    Items 1 - 25 of 102
    Component Evidence Code Pubs
    located_in neuron projection terminus PubMed 
    located_in neuronal cell body PubMed 
    located_in nuclear membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    prostaglandin E2 receptor EP4 subtype
    Names
    PGE receptor, EP4 subtype
    PGE2 receptor EP4 subtype
    prostaglandin E receptor 4 (subtype EP4)
    prostaglandin E2 receptor type 4
    prostanoid EP4 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032076.3NP_114465.3  prostaglandin E2 receptor EP4 subtype

      See identical proteins and their annotated locations for NP_114465.3

      Status: PROVISIONAL

      Source sequence(s)
      U94709
      UniProtKB/Swiss-Prot
      O08728, P43114
      UniProtKB/TrEMBL
      A0A0G2JSM6, A6KGE5
      Related
      ENSRNOP00000102242.1, ENSRNOT00000131156.1
      Conserved Domains (1) summary
      cd15142
      Location:18344
      7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      56061699..56074594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103261.2XP_038959189.1  prostaglandin E2 receptor EP4 subtype isoform X1

      UniProtKB/Swiss-Prot
      O08728, P43114
      UniProtKB/TrEMBL
      A0A0G2JSM6, A6KGE5
      Conserved Domains (1) summary
      cd15142
      Location:18344
      7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_006231996.5XP_006232058.1  prostaglandin E2 receptor EP4 subtype isoform X1

      See identical proteins and their annotated locations for XP_006232058.1

      UniProtKB/Swiss-Prot
      O08728, P43114
      UniProtKB/TrEMBL
      A0A0G2JSM6, A6KGE5
      Related
      ENSRNOP00000017886.3, ENSRNOT00000017886.7
      Conserved Domains (1) summary
      cd15142
      Location:18344
      7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
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