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    Trmu tRNA mitochondrial 2-thiouridylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trmuprovided by RGD
    Official Full Name
    tRNA mitochondrial 2-thiouridylaseprovided by RGD
    Primary source
    RGD:1311229
    See related
    EnsemblRapid:ENSRNOG00000016465 AllianceGenome:RGD:1311229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mtu1
    Summary
    Predicted to enable ATP binding activity; tRNA binding activity; and tRNA-5-taurinomethyluridine 2-sulfurtransferase. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 76.9), Adrenal (RPKM 67.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trmu in Genome Data Viewer
    Location:
    7q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (118849586..118866190)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (116969750..116987704)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (126756140..126772749)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene G-2 and S-phase expressed 1 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 1 Neighboring gene GRAM domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Infantile Liver Disease due to TRMU Gene Mutations: Three New Cases. Gaignard P, et al. JIMD Rep, 2013. PMID 23625533, Free PMC Article
    2. Acute infantile liver failure due to mutations in the TRMU gene. Zeharia A, et al. Am J Hum Genet, 2009 Sep. PMID 19732863, Free PMC Article
    3. Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase. Yan Q, et al. Biochim Biophys Acta, 2004 Jan 20. PMID 14746906
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-5-taurinomethyluridine 2-sulfurtransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial tRNA-specific 2-thiouridylase 1
    Names
    tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1
    tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
    NP_001129348.1
    NP_001388104.1
    XP_038935542.1
    XP_063120014.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135876.1 → NP_001129348.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform 1

      See identical proteins and their annotated locations for NP_001129348.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HTF7, D3ZLU4
      Related
      ENSRNOP00000022511.5, ENSRNOT00000022511.8
      Conserved Domains (2) summary
      cd01998
      Location:6 → 383
      tRNA_Me_trans; tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. ...
      pfam03054
      Location:5 → 383
      tRNA_Me_trans; tRNA methyl transferase

    2. NM_001401175.1 → NP_001388104.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      B1WC37
      Related
      ENSRNOP00000061254.1, ENSRNOT00000065283.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      118849586..118866190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079614.2 → XP_038935542.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X1

      Conserved Domains (1) summary
      pfam03054
      Location:5 → 293
      tRNA_Me_trans; tRNA methyl transferase

    2. XM_063263944.1 → XP_063120014.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X2

    RNA

    1. XR_005486683.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1WC37.1 GenPept UniProtKB/Swiss-Prot:B1WC37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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