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    Mto1 mitochondrial tRNA translation optimization 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mto1provided by RGD
    Official Full Name
    mitochondrial tRNA translation optimization 1provided by RGD
    Primary source
    RGD:1308830
    See related
    EnsemblRapid:ENSRNOG00000037659 AllianceGenome:RGD:1308830
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable flavin adenine dinucleotide binding activity. Predicted to be involved in mitochondrial tRNA wobble uridine modification and tRNA methylation. Predicted to act upstream of or within tRNA wobble uridine modification. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 83.6), Kidney (RPKM 83.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mto1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (88188918..88215516)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (79309681..79335231)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85807703..85832263)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene oocyte expressed protein Neighboring gene DEAD-box helicase 43 Neighboring gene trafficking protein particle complex subunit 14 like 1 Neighboring gene cyclic GMP-AMP synthase Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene uncharacterized LOC134480209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CircMTO1 Attenuated Acute Kidney Injury Through Regulating miR-337. Shi CC, et al. Inflammation, 2020 Aug. PMID 32157506, Free PMC Article
    2. Identification and characterization of mouse MTO1 gene related to mitochondrial tRNA modification. Li R, et al. Biochim Biophys Acta, 2003 Oct 1. PMID 14522080
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircMTO1 Attenuated Acute Kidney Injury Through Regulating miR-337.
      Title: CircMTO1 Attenuated Acute Kidney Injury Through Regulating miR-337.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitochondrial tRNA wobble uridine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA wobble uridine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein MTO1 homolog, mitochondrial
    Names
    mitochondrial translation optimization 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106841.1 → NP_001100311.1  protein MTO1 homolog, mitochondrial

      See identical proteins and their annotated locations for NP_001100311.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A6I1J8, F1LYH3
      Related
      ENSRNOP00000053966.5, ENSRNOT00000057138.6
      Conserved Domains (3) summary
      PRK05192
      Location:56 → 669
      PRK05192; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
      pfam13932
      Location:437 → 653
      GIDA_assoc; GidA associated domain
      cl21454
      Location:357 → 455
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      88188918..88215516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081156.2 → XP_038937084.1  protein MTO1 homolog, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK05192
      Location:72 → 563
      PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG

    2. XM_039081158.2 → XP_038937086.1  protein MTO1 homolog, mitochondrial isoform X3

      Conserved Domains (1) summary
      PRK05192
      Location:56 → 419
      PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG

    3. XM_039081157.2 → XP_038937085.1  protein MTO1 homolog, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK05192
      Location:2 → 487
      PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials