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    Suv39h2 SUV39H2 histone lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364785, updated on 27-Dec-2024

    Summary

    Official Symbol
    Suv39h2provided by RGD
    Official Full Name
    SUV39H2 histone lysine methyltransferaseprovided by RGD
    Primary source
    RGD:1306969
    See related
    EnsemblRapid:ENSRNOG00000015585 AllianceGenome:RGD:1306969
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cation binding activity; histone H3K9me2 methyltransferase activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including epigenetic regulation of gene expression; male meiotic nuclear division; and negative regulation of DNA-templated transcription. Predicted to act upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Predicted to be located in heterochromatin. Predicted to be active in nucleus. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 55.2), Testes (RPKM 30.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Suv39h2 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (79665467..79684492)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (74756290..74775332)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (78762897..78782016)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482747 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene uncharacterized LOC120097881 Neighboring gene DNA cross-link repair 1C Neighboring gene metallothionein 1, pseudogene 3 Neighboring gene meiosis/spermiogenesis associated 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromosome, centromeric region  
    located_in heterochromatin  
    is_active_in nucleus  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase SUV39H2
    Names
    suppressor of variegation 3-9 homolog 2
    NP_001102353.1
    XP_038951911.1
    XP_063132746.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108883.1NP_001102353.1  histone-lysine N-methyltransferase SUV39H2

      See identical proteins and their annotated locations for NP_001102353.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473990
      UniProtKB/TrEMBL
      A6JM14, D3ZIH5
      Related
      ENSRNOP00000020924.3, ENSRNOT00000020924.6
      Conserved Domains (4) summary
      smart00317
      Location:321450
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:236481
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam00385
      Location:119164
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam05033
      Location:225313
      Pre-SET; Pre-SET motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      79665467..79684492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095983.2XP_038951911.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

      Related
      ENSRNOP00000106598.1, ENSRNOT00000144553.1
      Conserved Domains (2) summary
      cd18639
      Location:148196
      CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
      cd10532
      Location:268510
      SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    2. XM_063276676.1XP_063132746.1  histone-lysine N-methyltransferase SUV39H2 isoform X2

      Related
      ENSRNOP00000104997.1, ENSRNOT00000147697.1
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