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    Tor1aip2 torsin 1A interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304881, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tor1aip2provided by RGD
    Official Full Name
    torsin 1A interacting protein 2provided by RGD
    Primary source
    RGD:735059
    See related
    EnsemblRapid:ENSRNOG00000024849 EnsemblRapid:ENSRNOG00000048267 AllianceGenome:RGD:735059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase activator activity and ATPase binding activity. Predicted to be involved in several processes, including endoplasmic reticulum organization; positive regulation of ATP-dependent activity; and protein localization to nuclear envelope. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human TOR1AIP2 (torsin 1A interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 206.9), Liver (RPKM 192.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tor1aip2 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (70775483..70806794)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (68225226..68256536)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (73704088..73735339)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096287 Neighboring gene centrosomal protein 350 Neighboring gene interferon induced transmembrane protein 2, pseudogene 2 Neighboring gene torsin 1A interacting protein 1 Neighboring gene family with sequence similarity 163, member A Neighboring gene uncharacterized LOC120096289 Neighboring gene ATP synthase F1 subunit gamma, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Clone Names

    • MGC72610

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity  
    enables ATPase activator activity  
    enables ATPase activator activity  
    enables ATPase binding  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum organization  
    involved_in endoplasmic reticulum organization  
    involved_in endoplasmic reticulum organization  
    involved_in membrane organization  
    involved_in positive regulation of ATP-dependent activity  
    involved_in positive regulation of ATP-dependent activity  
    involved_in protein localization to nuclear envelope  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in membrane  
    located_in nuclear envelope  

    General protein information

    Preferred Names
    torsin-1A-interacting protein 2; interferon alpha responsive protein
    Names
    torsin A interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165896.1 → NP_001159368.1  interferon alpha responsive protein isoform a

      See identical proteins and their annotated locations for NP_001159368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) shares a portion of its 5' UTR, but no coding sequence with variant 1. Variant 2 encodes a shorter protein (interferon alpha responsive protein), which is distinct from torsin-1A-interacting protein 2. Variants 2 and 3 encode the same protein, isoform a.
      Source sequence(s)
      CB804669, CO565924, CV107022, DV728294, EV767100
      UniProtKB/TrEMBL
      M0R5U6
      Related
      ENSRNOP00000071656.1, ENSRNOT00000077874.3
    2. NM_001165897.1 → NP_001159369.1  interferon alpha responsive protein isoform a

      See identical proteins and their annotated locations for NP_001159369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) shares a portion of its 5' UTR, but no coding sequence with variant 1. Variant 3 encodes a shorter protein, (interferon alpha responsive protein), which is distinct from torsin-1A-interacting protein 2. Variants 2 and 3 encode the same protein, isoform a.
      Source sequence(s)
      CB804669, CK478392, CO565924, DV728294, EV767100
      UniProtKB/TrEMBL
      M0R5U6
      Related
      ENSRNOP00000084434.1, ENSRNOT00000104928.2
    3. NM_199100.4 → NP_954531.1  torsin-1A-interacting protein 2 isoform b

      See identical proteins and their annotated locations for NP_954531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein, isoform b, referred to as torsin-1A-interacting protein 2.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      70775483..70806794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250045.5 → XP_006250107.1  torsin-1A-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006250107.1

      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    2. XM_039090736.2 → XP_038946664.1  torsin-1A-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    3. XM_039090735.2 → XP_038946663.1  torsin-1A-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Related
      ENSRNOP00000039176.3, ENSRNOT00000050734.6
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    4. XM_006250043.5 → XP_006250105.1  torsin-1A-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006250105.1

      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
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