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    Cdca2 cell division cycle associated 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305984, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cdca2provided by RGD
    Official Full Name
    cell division cycle associated 2provided by RGD
    Primary source
    RGD:1311003
    See related
    EnsemblRapid:ENSRNOG00000025302 AllianceGenome:RGD:1311003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Predicted to act upstream of or within chromosome segregation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromosome and nucleus. Orthologous to human CDCA2 (cell division cycle associated 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 305.1), Thymus (RPKM 107.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdca2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (46071360..46117524, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (41895946..41942226, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (44365396..44411601, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L36, pseudogene Neighboring gene uncharacterized LOC103693653 Neighboring gene potassium channel tetramerization domain containing 9 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene dedicator of cytokinesis 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. Wurzenberger C, et al. J Cell Biol, 2012 Jul 23. PMID 22801782, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431437.1 → NP_001418366.1  cell division cycle-associated protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6P9

    2. NM_001431438.1 → NP_001418367.1  cell division cycle-associated protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6P9

    3. NM_001431439.1 → NP_001418368.1  cell division cycle-associated protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6P9

    4. NM_001431440.1 → NP_001418369.1  cell division cycle-associated protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6P9

    5. NM_001431441.1 → NP_001418370.1  cell division cycle-associated protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZNC7

    6. NM_001431442.1 → NP_001418371.1  cell division cycle-associated protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZNC7

    7. NM_001431443.1 → NP_001418372.1  cell division cycle-associated protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZNC7

    8. NM_001431444.1 → NP_001418373.1  cell division cycle-associated protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZNC7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      46071360..46117524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599696.3 → XP_017455185.1  cell division cycle-associated protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15276
      Location:371 → 427
      PP1_bind; Protein phosphatase 1 binding

    2. XM_063274292.1 → XP_063130362.1  cell division cycle-associated protein 2 isoform X1

    3. XM_006252118.5 → XP_006252180.1  cell division cycle-associated protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15276
      Location:371 → 427
      PP1_bind; Protein phosphatase 1 binding

    4. XM_006252120.5 → XP_006252182.1  cell division cycle-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      A6K6P9
      Conserved Domains (1) summary
      pfam15276
      Location:370 → 426
      PP1_bind; Protein phosphatase 1 binding

    5. XM_006252117.5 → XP_006252179.1  cell division cycle-associated protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15276
      Location:371 → 427
      PP1_bind; Protein phosphatase 1 binding

    6. XM_008770757.4 → XP_008768979.1  cell division cycle-associated protein 2 isoform X4

      Conserved Domains (1) summary
      pfam15276
      Location:225 → 281
      PP1_bind; Protein phosphatase 1 binding

    7. XM_063274293.1 → XP_063130363.1  cell division cycle-associated protein 2 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107273.1: Suppressed sequence

      Description
      NM_001107273.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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