Adam23 ADAM metallopeptidase domain 23 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam23provided by RGD
Official Full Name: ADAM metallopeptidase domain 23provided by RGD
Primary source: RGD:1305739
See related: EnsemblRapid:ENSRNOG00000012424 AllianceGenome:RGD:1305739
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MDC3
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in glutamatergic synapse and presynaptic membrane. Orthologous to human ADAM23 (ADAM metallopeptidase domain 23). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 271.6), Liver (RPKM 66.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (72356479..72503545)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (64862649..65009718)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (70133969..70293312)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM22 and ADAM23 also associate with Caspr2 and TAG-1 (also known as CNTN2) to be selectively targeted to different axonal sub-regions. Hence, the combinatorial expression of Kv1-associated CAMs may be critical to tune intrinsic excitability in physiological and epileptogenic contexts.
Title: ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment.

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General gene information

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Markers

RH143531 (e-PCR)
- UniSTS:232777

D9UIA2 (e-PCR)
- UniSTS:239474

BF406113 (e-PCR)
- UniSTS:248282

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 23

Names: a disintegrin and metallopeptidase domain 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029899.3 → NP_001025070.3 disintegrin and metalloproteinase domain-containing protein 23 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

D3ZT36

Related

ENSRNOP00000042857.4, ENSRNOT00000040525.4
NM_001393708.2 → NP_001380637.2 disintegrin and metalloproteinase domain-containing protein 23 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AMQ9

Related

ENSRNOP00000106999.1, ENSRNOT00000161342.1