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    Tnrc6a trinucleotide repeat containing adaptor 6A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308971, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnrc6aprovided by RGD
    Official Full Name
    trinucleotide repeat containing adaptor 6Aprovided by RGD
    Primary source
    RGD:1307268
    See related
    EnsemblRapid:ENSRNOG00000024737 AllianceGenome:RGD:1307268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnrc6
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in P-body assembly; miRNA-mediated gene silencing by inhibition of translation; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cellular response to starvation and endoderm development. Predicted to be located in Golgi apparatus. Predicted to be part of RISC complex. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 6. Orthologous to human TNRC6A (trinucleotide repeat containing adaptor 6A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 150.0), Lung (RPKM 137.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnrc6a in Genome Data Viewer
    Location:
    1q36
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (186992457..187146764)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (177561898..177715669)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (192991584..193146403)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485175 Neighboring gene RB binding protein 6, ubiquitin ligase Neighboring gene uncharacterized LOC120099930 Neighboring gene RNA, U6 small nuclear 799 Neighboring gene uncharacterized LOC134483807 Neighboring gene solute carrier family 5 member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization. Nawalpuri B, et al. J Cell Sci, 2021 Aug 15. PMID 34328181
    2. Argonaute proteins at a glance. Ender C, et al. J Cell Sci, 2010 Jun 1. PMID 20484662
    3. Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Wakiyama M, et al. Genes Dev, 2007 Aug 1. PMID 17671087, Free PMC Article
    4. The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Huntzinger E, et al. Nucleic Acids Res, 2013 Jan. PMID 23172285, Free PMC Article
    5. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. Yang Z, et al. J Cell Sci, 2004 Nov 1. PMID 15494374

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization.
      Title: Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in P-body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trinucleotide repeat-containing gene 6A protein
    Names
    trinucleotide repeat containing 6
    trinucleotide repeat containing 6a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395157.2 → NP_001382086.1  trinucleotide repeat-containing gene 6A protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GAR2, F1M9Y8
      Related
      ENSRNOP00000083407.1, ENSRNOT00000096111.2
      Conserved Domains (5) summary
      pfam10427
      Location:1078 → 1203
      Ago_hook; Argonaute hook
      pfam12938
      Location:1298 → 1483
      M_domain; M domain of GW182
      pfam16608
      Location:1508 → 1769
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:1777 → 1868
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:604 → 863
      ser_rich_anae_1; serine-rich protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      186992457..187146764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759747.4 → XP_008757969.1  trinucleotide repeat-containing gene 6A protein isoform X1

      UniProtKB/TrEMBL
      F1M9Y8
      Conserved Domains (4) summary
      cd12711
      Location:1791 → 1873
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1081 → 1212
      Ago_hook; Argonaute hook
      pfam12938
      Location:1307 → 1492
      M_domain; M domain of GW182
      pfam16608
      Location:1515 → 1790
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    2. XM_017589208.3 → XP_017444697.1  trinucleotide repeat-containing gene 6A protein isoform X3

      UniProtKB/TrEMBL
      F1M9Y8

    3. XM_017589209.3 → XP_017444698.1  trinucleotide repeat-containing gene 6A protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6ASC0
      Related
      ENSRNOP00000107027.1, ENSRNOT00000145881.1
      Conserved Domains (4) summary
      cd12711
      Location:1742 → 1824
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1081 → 1212
      Ago_hook; Argonaute hook
      pfam12938
      Location:1292 → 1443
      M_domain; M domain of GW182
      pfam16608
      Location:1466 → 1741
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    4. XM_063263201.1 → XP_063119271.1  trinucleotide repeat-containing gene 6A protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6ASC0

    5. XM_008759749.4 → XP_008757971.1  trinucleotide repeat-containing gene 6A protein isoform X2

      UniProtKB/TrEMBL
      F1M9Y8
      Conserved Domains (4) summary
      cd12711
      Location:1780 → 1862
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1081 → 1201
      Ago_hook; Argonaute hook
      pfam12938
      Location:1296 → 1481
      M_domain; M domain of GW182
      pfam16608
      Location:1504 → 1779
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    6. XM_039078265.2 → XP_038934193.1  trinucleotide repeat-containing gene 6A protein isoform X7

      UniProtKB/TrEMBL
      F1M9Y8
      Conserved Domains (5) summary
      pfam10427
      Location:1034 → 1159
      Ago_hook; Argonaute hook
      pfam12938
      Location:1254 → 1439
      M_domain; M domain of GW182
      pfam16608
      Location:1464 → 1725
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:1733 → 1824
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:560 → 819
      ser_rich_anae_1; serine-rich protein

    7. XM_063263199.1 → XP_063119269.1  trinucleotide repeat-containing gene 6A protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6ASC0

    8. XM_063263213.1 → XP_063119283.1  trinucleotide repeat-containing gene 6A protein isoform X10

      UniProtKB/TrEMBL
      F1M9Y8

    9. XM_063263192.1 → XP_063119262.1  trinucleotide repeat-containing gene 6A protein isoform X4

      UniProtKB/TrEMBL
      F1M9Y8

    10. XM_063263204.1 → XP_063119274.1  trinucleotide repeat-containing gene 6A protein isoform X10

      UniProtKB/TrEMBL
      F1M9Y8

    11. XM_063263194.1 → XP_063119264.1  trinucleotide repeat-containing gene 6A protein isoform X5

      UniProtKB/TrEMBL
      A6I8Z0

    12. XM_063263221.1 → XP_063119291.1  trinucleotide repeat-containing gene 6A protein isoform X10

      UniProtKB/TrEMBL
      F1M9Y8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107549.2: Suppressed sequence

      Description
      NM_001107549.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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