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    Abhd11 abhydrolase domain containing 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360831, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Abhd11provided by RGD
    Official Full Name
    abhydrolase domain containing 11provided by RGD
    Primary source
    RGD:1304681
    See related
    EnsemblRapid:ENSRNOG00000018910 AllianceGenome:RGD:1304681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wbscr21; Abhd11l1
    Summary
    Predicted to enable lipase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Orthologous to human ABHD11 (abhydrolase domain containing 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 68.8), Heart (RPKM 56.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abhd11 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27318739..27322016, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21682206..21685331, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24722277..24725760, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene syntaxin 1A Neighboring gene ABHD11 antisense RNA 1 (tail to tail) Neighboring gene claudin 3 Neighboring gene ribosomal protein S13, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sn-1-specific diacylglycerol lipase ABHD11
    Names
    Williams Beuren syndrome chromosome region 21
    abhydrolase domain containing 11-like 1
    alpha/beta hydrolase domain-containing protein 11
    NP_001258109.1
    XP_063127622.1
    XP_063127623.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271180.1 → NP_001258109.1  sn-1-specific diacylglycerol lipase ABHD11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J0G1, D3ZXK4
      Conserved Domains (2) summary
      PRK10673
      Location:61 → 307
      PRK10673; acyl-CoA esterase; Provisional
      pfam12695
      Location:60 → 195
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      27318739..27322016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271552.1 → XP_063127622.1  sn-1-specific diacylglycerol lipase ABHD11 isoform X1

      UniProtKB/TrEMBL
      A6J0G1
      Related
      ENSRNOP00000025560.5, ENSRNOT00000025560.8

    2. XM_063271553.1 → XP_063127623.1  sn-1-specific diacylglycerol lipase ABHD11 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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