Parp10 poly (ADP-ribose) polymerase family, member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Parp10provided by RGD
Official Full Name: poly (ADP-ribose) polymerase family, member 10provided by RGD
Primary source: RGD:7744876
See related: EnsemblRapid:ENSRNOG00000004361 AllianceGenome:RGD:7744876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; NAD+-protein poly-ADP-ribosyltransferase activity; and transcription corepressor activity. Predicted to be involved in several processes, including post-translational protein modification; regulation of macromolecule metabolic process; and translesion synthesis. Predicted to be located in Golgi apparatus; cytosol; and nucleolus. Predicted to be active in cytoplasm and nucleus. Orthologous to human PARP10 (poly(ADP-ribose) polymerase family member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 127.8), Adrenal (RPKM 115.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109829721..109839054, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (107949031..107958377, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117291592..117300878, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: poly (ADP-ribose) polymerase family, member 10; protein mono-ADP-ribosyltransferase PARP10

Names: poly [ADP-ribose] polymerase 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432182.1 → NP_001419111.1 poly (ADP-ribose) polymerase family, member 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6AH37, D3ZZ94

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109829721..109839054 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241910.5 → XP_006241972.1 protein mono-ADP-ribosyltransferase PARP10 isoform X1

Related

ENSRNOP00000092715.1, ENSRNOT00000106920.2

Conserved Domains (4) summary

cd01439
Location:851 → 969

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd12547
Location:9 → 79

RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins

pfam00644
Location:785 → 971

PARP; Poly(ADP-ribose) polymerase catalytic domain

cl17169
Location:170 → 242

RRM_SF; RNA recognition motif (RRM) superfamily
XM_063264665.1 → XP_063120735.1 protein mono-ADP-ribosyltransferase PARP10 isoform X2
XM_039080535.2 → XP_038936463.1 protein mono-ADP-ribosyltransferase PARP10 isoform X3

Conserved Domains (2) summary

cd12547
Location:9 → 79

RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins

cl17169
Location:194 → 242

RRM_SF; RNA recognition motif (RRM) superfamily