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    Trim26 tripartite motif-containing 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309586, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Trim26provided by RGD
    Official Full Name
    tripartite motif-containing 26provided by RGD
    Primary source
    RGD:1359126
    See related
    EnsemblRapid:ENSRNOG00000032930 AllianceGenome:RGD:1359126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf173
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of non-canonical NF-kappaB signal transduction; and protein K11-linked ubiquitination. Predicted to be active in cytoplasm and nucleus. Orthologous to human TRIM26 (tripartite motif containing 26). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 69.9), Spleen (RPKM 58.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trim26 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (1711564..1736389, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (1708297..1731176, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2201685..2224481, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 10 Neighboring gene tripartite motif-containing 15, pseudogene 1 Neighboring gene tripartite motif containing 15 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene RT1 class I, locus M10, pseudogene 4 Neighboring gene RT1 class I, pseudogene 3298a3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. Uchil PD, et al. J Virol, 2013 Jan. PMID 23077300, Free PMC Article
    2. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Uchil PD, et al. PLoS Pathog, 2008 Feb 8. PMID 18248090, Free PMC Article
    3. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article
    4. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in suppression of viral release by host IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 26
    Names
    tripartite motif protein 26
    zinc finger protein 173
    NP_001011665.1
    XP_008770914.1
    XP_038954563.1
    XP_038954564.1
    XP_038954565.1
    XP_038954566.1
    XP_063135156.1
    XP_063135157.1
    XP_063135158.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011665.4 → NP_001011665.1  tripartite motif-containing protein 26

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P62603, Q6MFZ0
      UniProtKB/TrEMBL
      A0A0G2K415
      Related
      ENSRNOP00000001019.6, ENSRNOT00000001019.9
      Conserved Domains (3) summary
      smart00336
      Location:97 → 138
      BBOX; B-Box-type zinc finger
      cl02614
      Location:317 → 541
      SPRY; SPRY domain
      cl17238
      Location:16 → 56
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      1711564..1736389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098637.2 → XP_038954565.1  tripartite motif-containing protein 26 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K415
      Conserved Domains (4) summary
      cd16598
      Location:38 → 82
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:125 → 163
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
      NF033927
      Location:171 → 238
      alph_xenorhab_B; alpha-xenorhabdolysin family binary toxin subunit B
      cl02614
      Location:339 → 563
      SPRY; SPRY domain

    2. XM_039098635.2 → XP_038954563.1  tripartite motif-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K415, A0A8I6A8Z6
      Conserved Domains (4) summary
      cd16598
      Location:38 → 82
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:125 → 163
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
      NF033927
      Location:171 → 238
      alph_xenorhab_B; alpha-xenorhabdolysin family binary toxin subunit B
      cl02614
      Location:345 → 569
      SPRY; SPRY domain

    3. XM_039098638.2 → XP_038954566.1  tripartite motif-containing protein 26 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K415, A6KR89
      Conserved Domains (3) summary
      cd16598
      Location:13 → 57
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100 → 138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
      cl02614
      Location:320 → 544
      SPRY; SPRY domain

    4. XM_063279087.1 → XP_063135157.1  tripartite motif-containing protein 26 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K415

    5. XM_008772692.4 → XP_008770914.1  tripartite motif-containing protein 26 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K415, A6KR89
      Conserved Domains (3) summary
      cd16598
      Location:13 → 57
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100 → 138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
      cl02614
      Location:320 → 544
      SPRY; SPRY domain

    6. XM_063279086.1 → XP_063135156.1  tripartite motif-containing protein 26 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K415
      Related
      ENSRNOP00000098141.2, ENSRNOT00000120477.2

    7. XM_039098636.2 → XP_038954564.1  tripartite motif-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K415, A0A8I6A8Z6
      Related
      ENSRNOP00000098153.2, ENSRNOT00000120493.2
      Conserved Domains (4) summary
      cd16598
      Location:38 → 82
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:125 → 163
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
      NF033927
      Location:171 → 238
      alph_xenorhab_B; alpha-xenorhabdolysin family binary toxin subunit B
      cl02614
      Location:345 → 569
      SPRY; SPRY domain

    8. XM_063279088.1 → XP_063135158.1  tripartite motif-containing protein 26 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K415
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62603.1 GenPept UniProtKB/Swiss-Prot:P62603

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