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    Ppp2r1b protein phosphatase 2 scaffold subunit A beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315648, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ppp2r1bprovided by RGD
    Official Full Name
    protein phosphatase 2 scaffold subunit A betaprovided by RGD
    Primary source
    RGD:1304764
    See related
    EnsemblRapid:ENSRNOG00000010922 AllianceGenome:RGD:1304764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in several processes, including meiotic sister chromatid cohesion, centromeric; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and spindle assembly. Predicted to be located in membrane raft. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 166.4), Spleen (RPKM 86.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp2r1b in Genome Data Viewer
    Location:
    8q23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60092540..60125512)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51195860..51228442)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55279278..55311768)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ALG9, alpha-1,2-mannosyltransferase Neighboring gene uncharacterized LOC134480165 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene salt-inducible kinase 2 Neighboring gene transfer RNA proline (anticodon AGG) 89 Neighboring gene uncharacterized LOC120094336 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, et al. Cancer Lett, 2013 Jul 10. PMID 23454242, Free PMC Article
    2. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, et al. Mol Cell, 2010 Dec 22. PMID 21172653
    3. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
    4. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process involved in morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process involved in morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in meiotic sister chromatid cohesion, centromeric IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    Names
    protein phosphatase 2, regulatory subunit A, beta
    NP_001020589.1
    XP_017451115.3
    XP_017451116.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025418.1 → NP_001020589.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

      See identical proteins and their annotated locations for NP_001020589.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098007
      UniProtKB/Swiss-Prot
      Q4QQT4
      UniProtKB/TrEMBL
      A0A8I5ZR05, A6J4G5
      Related
      ENSRNOP00000080970.2, ENSRNOT00000115613.2
      Conserved Domains (4) summary
      pfam02985
      Location:295 → 325
      HEAT; HEAT repeat
      pfam13513
      Location:191 → 240
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:217 → 315
      HEAT_2; HEAT repeats
      sd00044
      Location:257 → 281
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      60092540..60125512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595626.3 → XP_017451115.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR05, A6J4G5
      Related
      ENSRNOP00000111967.1, ENSRNOT00000164239.1

    2. XM_017595627.3 → XP_017451116.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZR05, A0A8I6A483, A6J4G5
      Related
      ENSRNOP00000086717.1, ENSRNOT00000095678.2

    RNA

    1. XR_005487815.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QQT4.1 GenPept UniProtKB/Swiss-Prot:Q4QQT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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