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    Icoslg inducible T-cell co-stimulator ligand [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499415, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Icoslgprovided by RGD
    Official Full Name
    inducible T-cell co-stimulator ligandprovided by RGD
    Primary source
    RGD:1562791
    See related
    EnsemblRapid:ENSRNOG00000023109 AllianceGenome:RGD:1562791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Icosl; RGD1562791
    Summary
    Predicted to enable identical protein binding activity and receptor ligand activity. Predicted to be involved in T cell receptor signaling pathway; T follicular helper cell differentiation; and positive regulation of interleukin-4 production. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in external side of plasma membrane. Orthologous to human ICOSLG (inducible T cell costimulator ligand). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 208.8), Liver (RPKM 174.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Icoslg in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10600078..10610385, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10600420..10610718, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11330000..11340307, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase class 1 domain containing 3A Neighboring gene uncharacterized LOC134483782 Neighboring gene DNA methyltransferase 3 like Neighboring gene autoimmune regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein. Chattopadhyay K, et al. J Immunol, 2006 Sep 15. PMID 16951355
    2. ICOS is essential for effective T-helper-cell responses. Tafuri A, et al. Nature, 2001 Jan 4. PMID 11343123
    3. Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. Ling V, et al. J Immunol, 2000 Feb 15. PMID 10657606
    4. Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Mages HW, et al. Eur J Immunol, 2000 Apr. PMID 10760791
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T follicular helper cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ICOS ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427376.1 → NP_001414305.1  ICOS ligand isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      F1LVL2
      Related
      ENSRNOP00000031382.8, ENSRNOT00000038547.8

    2. NM_001427377.1 → NP_001414306.1  ICOS ligand isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      Related
      ENSRNOP00000089880.2, ENSRNOT00000098155.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      10600078..10610385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256262.5 → XP_006256324.1  ICOS ligand isoform X3

      UniProtKB/TrEMBL
      F1LVL2
      Conserved Domains (2) summary
      pfam07686
      Location:27 → 141
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:147 → 234
      Ig; Immunoglobulin domain

    2. XM_006256261.5 → XP_006256323.1  ICOS ligand isoform X2

      UniProtKB/TrEMBL
      F1LVL2
      Conserved Domains (2) summary
      pfam07686
      Location:26 → 140
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:146 → 233
      Ig; Immunoglobulin domain

    3. XM_006256260.5 → XP_006256322.1  ICOS ligand isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLT3, F1LVL2
      Conserved Domains (2) summary
      pfam07686
      Location:27 → 141
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:147 → 234
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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