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    Unc119 unc-119 lipid binding chaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29402, updated on 4-Jan-2025

    Summary

    Official Symbol
    Unc119provided by RGD
    Official Full Name
    unc-119 lipid binding chaperoneprovided by RGD
    Primary source
    RGD:3942
    See related
    EnsemblRapid:ENSRNOG00000011060 AllianceGenome:RGD:3942
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RRG4; Uncl19
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in several processes, including lipoprotein transport; negative regulation of endocytosis; and positive regulation of protein tyrosine kinase activity. Predicted to be located in cytoplasm. Predicted to be active in intercellular bridge and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 170.4), Spleen (RPKM 128.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Unc119 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63735927..63741404)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63237862..63243339)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65606919..65612324)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene aldolase, fructose-bisphosphate C Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class S Neighboring gene forkhead box N1 Neighboring gene ribosomal protein S2, pseudogene 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding  
    enables lipid binding  
    enables lipid binding  
    enables lipid binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis  
    involved_in lipoprotein transport  
    involved_in lipoprotein transport  
    involved_in lipoprotein transport  
    involved_in lipoprotein transport  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in negative regulation of caveolin-mediated endocytosis  
    involved_in negative regulation of caveolin-mediated endocytosis  
    involved_in negative regulation of caveolin-mediated endocytosis  
    involved_in negative regulation of clathrin-dependent endocytosis  
    involved_in negative regulation of clathrin-dependent endocytosis  
    involved_in negative regulation of clathrin-dependent endocytosis  
    involved_in nervous system development  
    involved_in positive regulation of protein tyrosine kinase activity  
    involved_in protein transport  
    involved_in visual perception  
    Component Evidence Code Pubs
    is_active_in centrosome  
    located_in centrosome  
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    is_active_in intercellular bridge  
    located_in intercellular bridge  
    located_in intercellular bridge  
    located_in intercellular bridge  
    is_active_in spindle midzone  
    located_in spindle midzone  
    located_in spindle midzone  
    located_in spindle midzone  
    is_active_in spindle pole  
    located_in spindle pole  
    located_in spindle pole  
    located_in spindle pole  

    General protein information

    Preferred Names
    protein unc-119 homolog A
    Names
    UNC-119 homolog
    retinal gene 4
    retinal protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017188.1NP_058884.1  protein unc-119 homolog A

      See identical proteins and their annotated locations for NP_058884.1

      Status: PROVISIONAL

      Source sequence(s)
      U40999
      UniProtKB/Swiss-Prot
      Q62885
      UniProtKB/TrEMBL
      A6HH44, A6HH45
      Related
      ENSRNOP00000015091.5, ENSRNOT00000015091.9
      Conserved Domains (1) summary
      pfam05351
      Location:81236
      GMP_PDE_delta; GMP-PDE, delta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63735927..63741404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268810.1XP_063124880.1  protein unc-119 homolog A isoform X1

    2. XM_039085739.2XP_038941667.1  protein unc-119 homolog A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AN70
      Related
      ENSRNOP00000095078.1, ENSRNOT00000107663.2
      Conserved Domains (1) summary
      pfam05351
      Location:10165
      GMP_PDE_delta; GMP-PDE, delta subunit
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