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    Mvk mevalonate kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81727, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mvkprovided by RGD
    Official Full Name
    mevalonate kinaseprovided by RGD
    Primary source
    RGD:621295
    See related
    EnsemblRapid:ENSRNOG00000049604 AllianceGenome:RGD:621295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MK; Lrbp
    Summary
    Enables several functions, including ATP binding activity; magnesium ion binding activity; and mevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and negative regulation of translation. Located in peroxisome. Human ortholog(s) of this gene implicated in hyperimmunoglobulinemia D periodic fever syndrome; lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 64.6), Liver (RPKM 63.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mvk in Genome Data Viewer
    Location:
    12q16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47802002..47819503, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42141391..42158893, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47904266..47920457, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481208 Neighboring gene transfer RNA alanine (anticodon AGC) 100 Neighboring gene metabolism of cobalamin associated B Neighboring gene ubiquitin protein ligase E3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables ATP binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables identical protein binding  
    enables mRNA binding PubMed 
    enables magnesium ion binding PubMed 
    enables mevalonate kinase activity  
    enables mevalonate kinase activity PubMed 
    enables mevalonate kinase activity  
    enables mevalonate kinase activity  
    enables protein binding PubMed 
    enables sequence-specific mRNA binding PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process  
    involved_in cholesterol biosynthetic process  
    involved_in cholesterol biosynthetic process  
    involved_in cholesterol biosynthetic process PubMed 
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway PubMed 
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway  
    involved_in isoprenoid biosynthetic process PubMed 
    involved_in isoprenoid biosynthetic process  
    involved_in isoprenoid metabolic process PubMed 
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of translation PubMed 
    involved_in regulation of cholesterol biosynthetic process PubMed 
    involved_in sterol metabolic process PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in peroxisome PubMed 
    NOT located_in peroxisome  

    General protein information

    Preferred Names
    mevalonate kinase
    Names
    LHR mRNA binding protein
    NP_001380631.1
    NP_112325.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393702.1 → NP_001380631.1  mevalonate kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5Y175
      Conserved Domains (1) summary
      cl40731
      Location:10 → 376
      PLN02677; mevalonate kinase
    2. NM_031063.2 → NP_112325.1  mevalonate kinase isoform 1

      See identical proteins and their annotated locations for NP_112325.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P17256
      UniProtKB/TrEMBL
      A0A8I5Y175, A6J1Z8
      Related
      ENSRNOP00000077122.1, ENSRNOT00000097267.2
      Conserved Domains (1) summary
      cl40731
      Location:10 → 377
      PLN02677; mevalonate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47802002..47819503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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