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    Ube2s ubiquitin-conjugating enzyme E2S [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292588, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2sprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2Sprovided by RGD
    Primary source
    RGD:1564746
    See related
    EnsemblRapid:ENSRNOG00000016930 AllianceGenome:RGD:1564746
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564746
    Summary
    Predicted to enable anaphase-promoting complex binding activity and ubiquitin conjugating enzyme activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; exit from mitosis; and protein polyubiquitination. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Orthologous to human UBE2S (ubiquitin conjugating enzyme E2 S). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 562.0), Thymus (RPKM 520.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ube2s in Genome Data Viewer
    Location:
    1q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78057659..78061719)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69028853..69032914)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72580424..72584484)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene shisa family member 7 Neighboring gene uncharacterized LOC134482885 Neighboring gene ribosomal protein L28 Neighboring gene transmembrane protein 238

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables anaphase-promoting complex binding  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    contributes_to ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    contributes_to ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process  
    involved_in anaphase-promoting complex-dependent catabolic process  
    involved_in cell division  
    involved_in exit from mitosis  
    involved_in exit from mitosis  
    involved_in free ubiquitin chain polymerization  
    involved_in free ubiquitin chain polymerization  
    involved_in positive regulation of ubiquitin protein ligase activity  
    involved_in positive regulation of ubiquitin protein ligase activity  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within protein K11-linked ubiquitination  
    involved_in protein K11-linked ubiquitination  
    involved_in protein K11-linked ubiquitination  
    involved_in protein K27-linked ubiquitination  
    involved_in protein K27-linked ubiquitination  
    involved_in protein K29-linked ubiquitination  
    involved_in protein K29-linked ubiquitination  
    involved_in protein K6-linked ubiquitination  
    involved_in protein K6-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein polyubiquitination  
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex  
    part_of anaphase-promoting complex  
    is_active_in nucleus  

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 S
    Names
    E2 ubiquitin-conjugating enzyme S
    ubiquitin carrier protein S
    ubiquitin-protein ligase S
    NP_001099694.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106224.2NP_001099694.1  ubiquitin-conjugating enzyme E2 S

      See identical proteins and their annotated locations for NP_001099694.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169077
      UniProtKB/Swiss-Prot
      B5DFI8
      Related
      ENSRNOP00000022977.4, ENSRNOT00000022977.7
      Conserved Domains (2) summary
      COG5078
      Location:9153
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:16152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78057659..78061719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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