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    Slc16a6 solute carrier family 16, member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303772, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc16a6provided by RGD
    Official Full Name
    solute carrier family 16, member 6provided by RGD
    Primary source
    RGD:735117
    See related
    EnsemblRapid:ENSRNOG00000000245 AllianceGenome:RGD:735117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MCT 6; MCT 7; Mct7B
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport and taurine transmembrane transport. Located in basolateral plasma membrane. Orthologous to human SLC16A6 (solute carrier family 16 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 79.5), Testes (RPKM 61.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc16a6 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (94923888..94946990, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94424377..94447482, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97733701..97758723, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 13 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene 5E5 antigen-like Neighboring gene arylsulfatase G Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene uncharacterized LOC100912202 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter. Higuchi K, et al. J Biol Chem, 2022 Apr. PMID 35257743, Free PMC Article
    2. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Price NT, et al. Biochem J, 1998 Jan 15. PMID 9425115, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94224

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in taurine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 7
    Names
    monocarboxylate transporter 6
    monocarboxylate transporter 7B
    solute carrier family 16 (monocarboxylic acid transporters), member 6
    solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415132.2 → NP_001402061.1  monocarboxylate transporter 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q7TMR7
      UniProtKB/TrEMBL
      A0A0G2JVH2, A6HKB2

    2. NM_001415133.2 → NP_001402062.1  monocarboxylate transporter 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HKB2, F7EP61
      Related
      ENSRNOP00000069483.2, ENSRNOT00000078059.3

    3. NM_198760.3 → NP_942055.1  monocarboxylate transporter 7 isoform 1

      See identical proteins and their annotated locations for NP_942055.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q7TMR7
      UniProtKB/TrEMBL
      A0A0G2JVH2, A6HKB2
      Conserved Domains (1) summary
      cd17422
      Location:24 → 471
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      94923888..94946990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247619.5 → XP_006247681.1  monocarboxylate transporter 7 isoform X2

      See identical proteins and their annotated locations for XP_006247681.1

      UniProtKB/Swiss-Prot
      Q7TMR7
      UniProtKB/TrEMBL
      A0A0G2JVH2, A6HKB2
      Conserved Domains (1) summary
      cd17422
      Location:24 → 471
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    2. XM_017597350.3 → XP_017452839.1  monocarboxylate transporter 7 isoform X1

      UniProtKB/TrEMBL
      A6HKB2
      Conserved Domains (1) summary
      cd17422
      Location:29 → 476
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    3. XM_039086229.2 → XP_038942157.1  monocarboxylate transporter 7 isoform X2

      UniProtKB/Swiss-Prot
      Q7TMR7
      UniProtKB/TrEMBL
      A0A0G2JVH2, A6HKB2
      Conserved Domains (1) summary
      cd17422
      Location:24 → 471
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    4. XM_039086231.2 → XP_038942159.1  monocarboxylate transporter 7 isoform X2

      UniProtKB/Swiss-Prot
      Q7TMR7
      UniProtKB/TrEMBL
      A0A0G2JVH2, A6HKB2
      Conserved Domains (1) summary
      cd17422
      Location:24 → 471
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMR7.1 GenPept UniProtKB/Swiss-Prot:Q7TMR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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