Azgp1 alpha-2-glycoprotein 1, zinc-binding [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Azgp1provided by RGD
Official Full Name: alpha-2-glycoprotein 1, zinc-bindingprovided by RGD
Primary source: RGD:2187
See related: EnsemblRapid:ENSRNOG00000001333 AllianceGenome:RGD:2187
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ZA2GA; Zna2gp
Summary: Involved in cellular response to insulin stimulus and cellular response to magnesium ion. Predicted to be active in external side of plasma membrane and extracellular space. Biomarker of chronic kidney disease; epilepsy; liver disease (multiple); obesity; and rheumatoid arthritis. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human AZGP1 (alpha-2-glycoprotein 1, zinc-binding). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 3096.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (22044685..22051248)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (16930990..16939333)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (19196565..19203094)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
Title: Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
Seizure-induced impairment in neuronal ketogenesis: Role of zinc-alpha2-glycoprotein in mitochondria.
Title: Seizure-induced impairment in neuronal ketogenesis: Role of zinc-α2-glycoprotein in mitochondria.
Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-alpha2-glycoprotein in primary cultured cortical neurons.
Title: Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-α2-glycoprotein in primary cultured cortical neurons.
TheZAG may inhibit TGFbeta-mediated ERK phosphorylation and inhibit neuroinflammation mediated by TNFalpha and IL-6, suggesting ZAG may suppress seizure via inhibiting neuroinflammation
Title: Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats.
Study reports expression of Zinc-alpha2-glycoprotein (ZAG) in neurons. The level of ZAG was lower in temporal lobe epilepsy patients and time-dependently decreased in PTZ-treated rats. In addition, ZAG was shown to interact with p-ERK and TGF-beta. ZAG was found to be synthesized in neurons, and both the AZGP1 mRNA and ZAG protein levels were decreased in epilepsy patients and rat models.
Title: Neuronal zinc-α2-glycoprotein is decreased in temporal lobe epilepsy in patients and rats.
AZGP1 is a negative regulator of fibrosis progression in kidney and heart
Title: Zinc-α2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart.
Overproduction of ZAG in white adipose tissue in chronic kidney disease could be a major contributor to metabolic disturbances associated with CKD.
Title: White adipose tissue overproduces the lipid-mobilizing factor zinc α2-glycoprotein in chronic kidney disease.

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General gene information

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Markers

RH142182 (e-PCR)
- UniSTS:231432

RH138481 (e-PCR)
- UniSTS:220568

RH94525 (e-PCR)
- UniSTS:119773

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: zinc-alpha-2-glycoprotein

Names: Zn - alpha2 - glycoprotein; alpha-2 - glycoprotein 1, zinc; alpha-2-glycoprotein 1, zinc; zn-alpha-2-GP; zn-alpha-2-glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012826.2 → NP_036958.2 zinc-alpha-2-glycoprotein precursor

See identical proteins and their annotated locations for NP_036958.2

Status: PROVISIONAL

Source sequence(s)

BC105822

UniProtKB/Swiss-Prot

Q63523, Q63678

UniProtKB/TrEMBL

A0A8I6A9I2, A6KSS1, Q3B8R6

Related

ENSRNOP00000001801.5, ENSRNOT00000001801.8

Conserved Domains (2) summary

cl08246
Location:21 → 196

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cl11960
Location:200 → 291

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

22044685..22051248

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249003.5 → XP_006249065.1 zinc-alpha-2-glycoprotein isoform X1

UniProtKB/Swiss-Prot

Q63523, Q63678

Conserved Domains (2) summary

cl08246
Location:21 → 242

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cl11960
Location:246 → 337

Ig; Immunoglobulin domain
XM_006249004.5 → XP_006249066.1 zinc-alpha-2-glycoprotein isoform X2

UniProtKB/Swiss-Prot

Q63523, Q63678

UniProtKB/TrEMBL

F7F110

Related

ENSRNOP00000088478.2, ENSRNOT00000102149.2

Conserved Domains (2) summary

cl08246
Location:21 → 237

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cl11960
Location:241 → 332

Ig; Immunoglobulin domain