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    Dsp desmoplakin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306871, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dspprovided by RGD
    Official Full Name
    desmoplakinprovided by RGD
    Primary source
    RGD:1305794
    See related
    EnsemblRapid:ENSRNOG00000013928 AllianceGenome:RGD:1305794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DP
    Summary
    Predicted to enable protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Predicted to be involved in several processes, including intermediate filament organization; regulation of heart contraction; and ventricular compact myocardium morphogenesis. Predicted to act upstream of or within adherens junction organization; desmosome organization; and epithelial cell-cell adhesion. Located in desmosome and fascia adherens. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; dilated cardiomyopathy; and keratosis palmoplantaris striata 2. Orthologous to human DSP (desmoplakin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1641.4), Adrenal (RPKM 305.2) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Dsp in Genome Data Viewer
    Location:
    17p12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (26829153..26877419, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (26623602..26671692, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (27286811..27334453, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 48 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102546383 Neighboring gene RIO kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase C binding  
    enables scaffold protein binding  
    enables structural molecule activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adherens junction organization  
    involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication  
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within cell-cell adhesion  
    acts_upstream_of_or_within desmosome organization  
    involved_in desmosome organization  
    acts_upstream_of_or_within epithelial cell-cell adhesion  
    involved_in intermediate filament cytoskeleton organization  
    acts_upstream_of_or_within intermediate filament cytoskeleton organization  
    involved_in intermediate filament organization  
    involved_in keratinocyte differentiation  
    involved_in peptide cross-linking  
    involved_in protein localization to cell-cell junction  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of ventricular cardiac muscle cell action potential  
    involved_in skin development  
    acts_upstream_of_or_within skin development  
    involved_in ventricular compact myocardium morphogenesis  
    involved_in wound healing  
    Component Evidence Code Pubs
    NOT located_in adherens junction PubMed 
    located_in adherens junction  
    located_in basolateral plasma membrane  
    located_in cell-cell junction  
    located_in cornified envelope  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in desmosome PubMed 
    located_in desmosome  
    located_in fascia adherens PubMed 
    is_active_in intercalated disc  
    located_in intercalated disc  
    colocalizes_with intermediate filament  
    located_in intermediate filament  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419598.1NP_001406527.1  desmoplakin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      F1LMV6, Q4QQR7
      UniProtKB/TrEMBL
      A6J7B0
      Related
      ENSRNOP00000018649.5, ENSRNOT00000018649.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      26829153..26877419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600713.3XP_017456202.1  desmoplakin isoform X1

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