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    Dcxr dicarbonyl and L-xylulose reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171408, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dcxrprovided by RGD
    Official Full Name
    dicarbonyl and L-xylulose reductaseprovided by RGD
    Primary source
    RGD:620031
    See related
    EnsemblRapid:ENSRNOG00000081885 AllianceGenome:RGD:620031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    glb
    Summary
    Enables L-xylulose reductase (NADPH) activity. Involved in glucose metabolic process and xylulose metabolic process. Predicted to be located in several cellular components, including brush border; cytoplasmic microtubule; and microvillus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 680.0), Liver (RPKM 409.2) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Dcxr in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106504730..106506619, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106006404..106008293, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109906119..109909696, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36a-like Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3 Neighboring gene carbonyl reductase 2 Neighboring gene transfer RNA glycine (anticodon ACC) 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in brush border  
    located_in cytoplasmic microtubule  
    located_in cytoplasmic microtubule  
    is_active_in cytosol  
    located_in membrane  
    located_in microvillus  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    L-xylulose reductase
    Names
    XR
    diacetyl/L-xylulose reductase
    dicarbonyl L-xylulose reductase
    NP_599214.1
    XP_038941084.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134387.2NP_599214.1  L-xylulose reductase

      See identical proteins and their annotated locations for NP_599214.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q920P0
      UniProtKB/TrEMBL
      A6HLI7, A6HLI8
      Related
      ENSRNOP00000108490.1, ENSRNOT00000168618.1
      Conserved Domains (1) summary
      cd05351
      Location:1243
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106504730..106506619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085156.2XP_038941084.1  L-xylulose reductase isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:1122
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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