Avpr1b arginine vasopressin receptor 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Avpr1bprovided by RGD
Official Full Name: arginine vasopressin receptor 1Bprovided by RGD
Primary source: RGD:6502812
See related: EnsemblRapid:ENSRNOG00000048522 AllianceGenome:RGD:6502812
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: V1bR; AVPR V3; AVPR V1b
Summary: Enables identical protein binding activity; peptide hormone binding activity; and vasopressin receptor activity. Involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; positive regulation of cellular pH reduction; and positive regulation of glutamate secretion. Located in dendrite. Used to study anxiety disorder and depressive disorder. Biomarker of alcohol dependence. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 1.5), Heart (RPKM 0.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (45598116..45611680)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (43046531..43059046)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (48390434..48400583, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

2% salt-drinking rats had increased levels of V1bR in the hypothalamus and choroid plexus.
Title: Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus.
Results show that both Avpr1a and b are involved in anxiety-related responses, and suggest that different fear responses are under the control of specific AVP receptor systems within discrete parts of the hippocampus.
Title: Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus.
we focus on the genetic and pharmacological studies that have implicated the Avpr1b in the neural regulation of social behaviors, including social forms of aggressive behavior, social memory, and social motivation--REVIEW
Title: The vasopressin 1b receptor and the neural regulation of social behavior.
Vasopressin and v1br gene expression is increased in the hypothalamic pvn of borderline hypertensive rats.
Title: Vasopressin and v1br gene expression is increased in the hypothalamic pvn of borderline hypertensive rats.
V1BR receptors are almost exclusively present on alpha-glucagon cells in the pancreas.
Title: Acute and chronic hyperglycemic effects of vasopressin in normal rats: involvement of V(1A) receptors.
data show that regulation of internal ribosome entry site activity in the 5'UTR of the V1bR mRNA probably through phosphorylation of eIF4G may serve as a mechanism for rapid changes in V1bR translation to meet physiological demands
Title: Translational regulation of the vasopressin v1b receptor involves an internal ribosome entry site.
compared expression of V1a, V1b and V2 vasopressin receptor mRNA in the renal cortex, renal medulla and the heart of hypertensive renin transgenic TGR(mRen2)27 rats (TGR) and of their parent normotensive Sprague Dawley (SD) strain
Title: Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats.
The positive role of arginine vasopressin (AVP) in the regulation of adrenocorticotropic hormone secretion from the pituitary in animals exposed to heat is confirmed. AVP from the general circulation influences pituitary vasopressin 1b receptor.
Title: The effect of vasopressin 1b receptor (V1bR) blockade on HPA axis activity in rats exposed to acute heat stress.
mRNA expression for V(1a) and V(1b) AVP receptors in isolated rat adrenal chromaffin cells treated with vasopressin
Title: Effects of vasopressin on isolated rat adrenal chromaffin cells.
study demonstrates that interactions of GAGA-binding proteins with the GAGA box of the V1bR promoter activate V1bR gene expression and provides a potential mechanism for physiological regulation of V1bR transcription
Title: Transcriptional regulation of the pituitary vasopressin V1b receptor involves a GAGA-binding protein.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables vasopressin receptor activity	IEA Inferred from Electronic Annotation more info
enables vasopressin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables vasopressin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular pH reduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by vasopressin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by vasopressin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by vasopressin	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vasopressin V1b receptor

Names: antidiuretic hormone receptor 1b; vasopressin V3 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289800.2 → NP_001276729.1 vasopressin V1b receptor

See identical proteins and their annotated locations for NP_001276729.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P48974

UniProtKB/TrEMBL

A6IC22, G3V6U8

Related

ENSRNOP00000064689.1, ENSRNOT00000074512.4

Conserved Domains (3) summary

pfam00001
Location:51 → 335

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam08983
Location:359 → 408

DUF1856; Domain of unknown function (DUF1856)

cl21561
Location:41 → 184

7tm_4; Olfactory receptor