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    Ppp1r7 protein phosphatase 1, regulatory subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301618, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp1r7provided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 7provided by RGD
    Primary source
    RGD:1308169
    See related
    EnsemblRapid:ENSRNOG00000016974 AllianceGenome:RGD:1308169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sds22
    Summary
    Predicted to act upstream of or within chromosome segregation. Predicted to be located in chromosome. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 141.9), Thymus (RPKM 82.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r7 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101333472..101358589)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (93886068..93911198)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (99556587..100504077)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated domain-containing protein 1 pseudogene Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene protein NYNRIN-like Neighboring gene U6 spliceosomal RNA Neighboring gene anoctamin 7 Neighboring gene high density lipoprotein binding protein Neighboring gene uncharacterized LOC120094809

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei. Tran HT, et al. Biochem Cell Biol, 2002. PMID 12555814
    2. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. Renouf S, et al. FEBS Lett, 1995 Nov 13. PMID 7498485
    3. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. Ceulemans H, et al. J Biol Chem, 2002 Dec 6. PMID 12226088
    4. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. Wurzenberger C, et al. J Cell Biol, 2012 Jul 23. PMID 22801782, Free PMC Article
    5. Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS. Moser K, et al. J Proteome Res, 2006 Jan. PMID 16396499

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 are found in rat liver nuclei
      Title: Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei.
    2. conserved portion of Sds22 folds into a curved superhelix; demonstrate that mutation to alanine of any of eight residues at the concave surface of this superhelix thwarts the interaction with PP1 [Sds22]
      Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105784

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 7
    Names
    protein phosphatase 1 regulatory subunit 22
    protein phosphatase 1, regulatory (inhibitor) subunit 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009825.2 → NP_001009825.1  protein phosphatase 1 regulatory subunit 7

      See identical proteins and their annotated locations for NP_001009825.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5HZV9
      UniProtKB/TrEMBL
      A0A8I6AM99, A6JQY6
      Related
      ENSRNOP00000081944.1, ENSRNOT00000095497.2
      Conserved Domains (3) summary
      sd00033
      Location:100 → 121
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:68 → 260
      internalin_A; class 1 internalin InlA
      cd21340
      Location:169 → 354
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101333472..101358589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767362.4 → XP_008765584.1  protein phosphatase 1 regulatory subunit 7 isoform X1

      Conserved Domains (2) summary
      sd00033
      Location:100 → 121
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:97 → 272
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZV9.1 GenPept UniProtKB/Swiss-Prot:Q5HZV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools