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    Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cox10provided by RGD
    Official Full Name
    cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10provided by RGD
    Primary source
    RGD:1594623
    See related
    EnsemblRapid:ENSRNOG00000024972 AllianceGenome:RGD:1594623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable farnesyltranstransferase activity and protoheme IX farnesyltransferase activity. Predicted to be involved in heme A biosynthetic process; heme O biosynthetic process; and respiratory chain complex IV assembly. Predicted to act upstream of or within several processes, including copper ion homeostasis; cytochrome complex assembly; and mitochondrial fission. Predicted to be located in cytosol and nucleolus. Predicted to be part of cytochrome complex. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 135.1), Muscle (RPKM 106.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox10 in Genome Data Viewer
    Location:
    10q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (49130209..49242009, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (48630993..48742805, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (50439778..50563920, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095117 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 3B1 Neighboring gene uncharacterized LOC120095119 Neighboring gene uncharacterized LOC120095118 Neighboring gene transfer RNA glutamine (anticodon CUG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytochrome c oxidase is required for the assembly/stability of respiratory complex I in mouse fibroblasts. Diaz F, et al. Mol Cell Biol, 2006 Jul. PMID 16782876, Free PMC Article
    2. Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency. Antonicka H, et al. Hum Mol Genet, 2003 Oct 15. PMID 12928484
    3. A mutation in the human heme A:farnesyltransferase gene (COX10 ) causes cytochrome c oxidase deficiency. Valnot I, et al. Hum Mol Genet, 2000 May 1. PMID 10767350
    4. Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant. Glerum DM, et al. Proc Natl Acad Sci U S A, 1994 Aug 30. PMID 8078902, Free PMC Article
    5. Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1. Williams SL, et al. J Biol Chem, 2004 Feb 27. PMID 14607829

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables farnesyltranstransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protoheme IX farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protoheme IX farnesyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within copper ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytochrome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme O biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within leukocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory chain complex IV assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cytochrome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
    Names
    COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
    COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase
    cytochrome c oxidase assembly homolog 10
    protoheme IX farnesyltransferase, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398997.1 → NP_001385926.1  cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFE3, F1LVF4
      Related
      ENSRNOP00000029439.6, ENSRNOT00000034261.7
      Conserved Domains (1) summary
      cd13957
      Location:158 → 413
      PT_UbiA_Cox10; Protoheme IX farnesyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      49130209..49242009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269908.1 → XP_063125978.1  cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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