Mettl9 methyltransferase 9, His-X-His N1(pi)-histidine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl9provided by RGD
Official Full Name: methyltransferase 9, His-X-His N1(pi)-histidineprovided by RGD
Primary source: RGD:2311609
See related: EnsemblRapid:ENSRNOG00000025940 AllianceGenome:RGD:2311609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein-L-histidine N-pros-methyltransferase activity. Predicted to be located in mitochondrion. Predicted to be active in endoplasmic reticulum. Orthologous to human METTL9 (methyltransferase 9, His-X-His N1(pi)-histidine). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 157.9), Adrenal (RPKM 123.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (185006953..185054359)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (175575805..175623065)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (190962935..191009926)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.
Title: Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.

Submit: New GeneRIF Correction

General gene information

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Markers

RH124470 (e-PCR)
- UniSTS:161292

BE105359 (e-PCR)
- UniSTS:245814

AU047751 (e-PCR)
- UniSTS:110202

RH134210 (e-PCR)
- UniSTS:217492

RH141725 (e-PCR)
- UniSTS:223718

RH134056 (e-PCR)
- UniSTS:217338

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-L-histidine N-pros-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: protein-L-histidine N-pros-methyltransferase

Names: methyltransferase 9, His-X-His N1-histidine; methyltransferase like 9; methyltransferase-like protein 9

NP_001156636.1

EC 2.1.1.-

XP_006230216.1

EC 2.1.1.-

XP_008757880.1

EC 2.1.1.-

XP_008757881.1

EC 2.1.1.-

XP_063140139.1

EC 2.1.1.-

XP_063140378.1

EC 2.1.1.-

XP_063140645.1

EC 2.1.1.-

XP_063140947.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163164.1 → NP_001156636.1 protein-L-histidine N-pros-methyltransferase

See identical proteins and their annotated locations for NP_001156636.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I8T8, G0Z7P9

Conserved Domains (1) summary

pfam05219
Location:56 → 317

DREV; DREV methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

185006953..185054359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759659.4 → XP_008757881.1 protein-L-histidine N-pros-methyltransferase isoform X3

UniProtKB/TrEMBL

G0Z7P9

Conserved Domains (1) summary

pfam05219
Location:16 → 277

DREV; DREV methyltransferase
XM_063284069.1 → XP_063140139.1 protein-L-histidine N-pros-methyltransferase isoform X4

UniProtKB/TrEMBL

G0Z7P9
XM_006230154.4 → XP_006230216.1 protein-L-histidine N-pros-methyltransferase isoform X1

UniProtKB/TrEMBL

G0Z7P9

Related

ENSRNOP00000037064.4, ENSRNOT00000039186.5

Conserved Domains (1) summary

pfam05219
Location:56 → 316

DREV; DREV methyltransferase
XM_063284308.1 → XP_063140378.1 protein-L-histidine N-pros-methyltransferase isoform X5
XM_063284877.1 → XP_063140947.1 protein-L-histidine N-pros-methyltransferase isoform X7
XM_008759658.3 → XP_008757880.1 protein-L-histidine N-pros-methyltransferase isoform X2

UniProtKB/TrEMBL

A6I8T9

Related

ENSRNOP00000102286.1, ENSRNOT00000141315.1

Conserved Domains (1) summary

cl17173
Location:56 → 251

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063284575.1 → XP_063140645.1 protein-L-histidine N-pros-methyltransferase isoform X6

UniProtKB/TrEMBL

C3VPW1