Vcpkmt valosin containing protein lysine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Vcpkmtprovided by RGD
Full Name: valosin containing protein lysine methyltransferaseprovided by RGD
Primary source: RGD:7565188
See related: AllianceGenome:RGD:7565188
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mettl21d; RGD1306228
Summary: Predicted to enable ATPase binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of ATP-dependent activity and peptidyl-lysine trimethylation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Orthologous to human VCPKMT (valosin containing protein lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 82.4), Brain (RPKM 78.1) and 9 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (93772558..93778400, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (88036485..88042151, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (91880342..91884336, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine trimethylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

Preferred Names: protein N-lysine methyltransferase METTL21D; valosin containing protein lysine methyltransferase

Names: methyltransferase like 21D; methyltransferase-like protein 21D; protein-lysine methyltransferase METTL21D; protein-lysine methyltransferase METTL21D-like; valosin containing protein lysine (K) methyltransferase

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_063262661.1 → XP_063118731.1 protein N-lysine methyltransferase METTL21D isoform X3
XM_063262660.1 → XP_063118730.1 protein N-lysine methyltransferase METTL21D isoform X1
XM_039113221.2 → XP_038969149.1 protein N-lysine methyltransferase METTL21D isoform X2

Conserved Domains (1) summary

cl17173
Location:1 → 111

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063262662.1 → XP_063118732.1 protein N-lysine methyltransferase METTL21D isoform X4