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    Zic3 Zic family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367944, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zic3provided by RGD
    Official Full Name
    Zic family member 3provided by RGD
    Primary source
    RGD:1561261
    See related
    AllianceGenome:RGD:1561261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561261
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including nervous system development; regionalization; and regulation of DNA-templated transcription. Predicted to act upstream of or within anterior/posterior pattern specification and heart looping. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in X-linked VACTERL association; situs inversus; and visceral heterotaxy. Orthologous to human ZIC3 (Zic family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 11.9) and Adrenal (RPKM 1.3) See more
    Orthologs
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    Genomic context

    See Zic3 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (141159623..141165587)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (136123662..136129627)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (140875191..140888344)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18, pseudogene 13 Neighboring gene ribosomal protein L27, pseudogene 6 Neighboring gene high-mobility group box 4, pseudogene 3 Neighboring gene high mobility group protein B4-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 46
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification  
    involved_in atrial cardiac muscle tissue development  
    involved_in axial mesoderm development  
    involved_in biological_process  
    involved_in central nervous system development  
    involved_in central nervous system segmentation  
    involved_in cranial skeletal system development  
    involved_in determination of digestive tract left/right asymmetry  
    involved_in determination of left/right asymmetry in nervous system  
    acts_upstream_of_or_within determination of left/right symmetry  
    involved_in determination of left/right symmetry  
    involved_in determination of liver left/right asymmetry  
    involved_in determination of pancreatic left/right asymmetry  
    involved_in embryonic pattern specification  
    involved_in face development  
    involved_in forebrain development  
    involved_in gastrulation  
    involved_in gene expression  
    involved_in germ-line stem cell population maintenance  
    involved_in heart development  
    acts_upstream_of_or_within heart looping  
    involved_in heart looping  
    involved_in hippocampus development  
    involved_in left/right axis specification  
    involved_in left/right pattern formation  
    involved_in limb morphogenesis  
    involved_in lung development  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in maintenance of cell number  
    involved_in mesoderm development  
    involved_in neural plate development  
    involved_in neuron differentiation  
    involved_in olfactory bulb development  
    involved_in outer ear morphogenesis  
    involved_in paraxial mesoderm development  
    acts_upstream_of_or_within pattern specification process  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in primitive streak formation  
    involved_in regulation of DNA-binding transcription factor activity  
    involved_in skeletal system development  
    involved_in smoothened signaling pathway  
    involved_in stem cell differentiation  
    involved_in stem cell population maintenance  
    Items 1 - 25 of 46
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein ZIC 3
    Names
    Zic family member 3 (odd-paired homolog, Drosophila)
    zinc finger protein of the cerebellum 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411817.2NP_001398746.1  zinc finger protein ZIC 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A096MIX7, A6K4Z3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      141159623..141165587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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