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    Hapln1 hyaluronan and proteoglycan link protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29331, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Hapln1provided by RGD
    Official Full Name
    hyaluronan and proteoglycan link protein 1provided by RGD
    Primary source
    RGD:2412
    See related
    EnsemblRapid:ENSRNOG00000032002 AllianceGenome:RGD:2412
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crtl1
    Summary
    Predicted to enable hyaluronic acid binding activity and structural molecule activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space; perineuronal net; and synapse. Orthologous to human HAPLN1 (hyaluronan and proteoglycan link protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 94.9), Heart (RPKM 9.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hapln1 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (22366967..22431709)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (20631640..20696388)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (18354542..18419077)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 7 Neighboring gene versican Neighboring gene uncharacterized LOC134485711

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway. Yan T, et al. BMC Cardiovasc Disord, 2024 Apr 5. PMID 38580957, Free PMC Article
    2. The primary structure of link protein from rat chondrosarcoma proteoglycan aggregate. Neame PJ, et al. J Biol Chem, 1986 Mar 15. PMID 2419334
    3. Alternative splicing generates two different mRNA species for rat link protein. Rhodes C, et al. J Biol Chem, 1988 May 5. PMID 2452158
    4. Link protein cDNA sequence reveals a tandemly repeated protein structure. Doege K, et al. Proc Natl Acad Sci U S A, 1986 Jun. PMID 3459153, Free PMC Article
    5. Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells. Sun GW, et al. Endocrinology, 2003 Mar. PMID 12586755

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway.
      Title: HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway.
    2. Hyaluronan and Proteoglycan Link Protein 1 Activates the BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic Differentiation: an Implication in Fracture Healing.
      Title: Hyaluronan and Proteoglycan Link Protein 1 Activates the BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic Differentiation: an Implication in Fracture Healing.
    3. our findings demonstrate that the formation of perineuronal nets triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS
      Title: Animals lacking link protein have attenuated perineuronal nets and persistent plasticity.
    4. HAPLN1 may promote periovulatory granulosa cell survival, which would facilitate their differentiation into luteal cells.
      Title: Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function.
    5. study represents the first report that follicle stimulating hormone amplifies insulin-like growth factor-I-mediated cartilage link protein Crtl1 production, possibly via phosphatidylinositol 3-kinase-Akt signaling cascades in rat granulosa cells
      Title: Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells.
    6. Aggrecan, hyaluronan synthases, and, particularly, link protein 1 might be crucial elements for the initial assembly of perineuronal nets.
      Title: Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156657

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hyaluronic acid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perineuronal net IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hyaluronan and proteoglycan link protein 1
    Names
    LP
    cartilage link protein 1
    cartilage-link protein
    cartilage-linking protein 1
    proteoglycan link protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019189.2 → NP_062062.2  hyaluronan and proteoglycan link protein 1 precursor

      See identical proteins and their annotated locations for NP_062062.2

      Status: PROVISIONAL

      Source sequence(s)
      BC128740
      UniProtKB/TrEMBL
      A1A5N6, A6I4N0
      Related
      ENSRNOP00000045959.2, ENSRNOT00000042958.7
      Conserved Domains (4) summary
      cd05877
      Location:53 → 160
      Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP)
      smart00410
      Location:54 → 155
      IG_like; Immunoglobulin like
      cd03518
      Location:159 → 253
      Link_domain_HAPLN_module_1; Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding ...
      cd03519
      Location:260 → 350
      Link_domain_HAPLN_module_2; Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      22366967..22431709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231748.5 → XP_006231810.1  hyaluronan and proteoglycan link protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006231810.1

      UniProtKB/Swiss-Prot
      P03994
      UniProtKB/TrEMBL
      A6I4N0
      Conserved Domains (3) summary
      cd03518
      Location:159 → 253
      Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd03519
      Location:260 → 350
      Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd05877
      Location:43 → 161
      Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains

    2. XM_039101883.2 → XP_038957811.1  hyaluronan and proteoglycan link protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P03994
      UniProtKB/TrEMBL
      A6I4N0
      Conserved Domains (3) summary
      cd03518
      Location:159 → 253
      Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd03519
      Location:260 → 350
      Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
      cd05877
      Location:43 → 161
      Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03994.2 GenPept UniProtKB/Swiss-Prot:P03994

    Gene LinkOut

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