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    Khdrbs3 KH RNA binding domain containing, signal transduction associated 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64015, updated on 9-Dec-2024

    Summary

    Official Symbol
    Khdrbs3provided by RGD
    Official Full Name
    KH RNA binding domain containing, signal transduction associated 3provided by RGD
    Primary source
    RGD:620921
    See related
    EnsemblRapid:ENSRNOG00000009539 AllianceGenome:RGD:620921
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Etle; Slm2
    Summary
    Enables single-stranded RNA binding activity. Involved in mRNA processing; regulation of RNA splicing; and spermatogenesis. Located in nucleus. Orthologous to human KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 349.1), Testes (RPKM 143.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Khdrbs3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (102726628..102884545)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (100837707..100995644)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (110031819..110179475)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479744 Neighboring gene TOX high mobility group box family member 4, pseudogene 1 Neighboring gene uncharacterized LOC108351507 Neighboring gene uncharacterized LOC134479745 Neighboring gene R3H domain containing 2, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding  
    enables RNA binding  
    enables SH3 domain binding  
    enables identical protein binding  
    enables identical protein binding  
    enables mRNA binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables single-stranded RNA binding PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    KH domain-containing, RNA-binding, signal transduction-associated protein 3
    Names
    KH domain containing, RNA binding, signal transduction associated 3
    SLM-2
    etoile, Sam68-like protein SLM-2
    rSLM-2
    sam68-like mammalian protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022249.2NP_071585.2  KH domain-containing, RNA-binding, signal transduction-associated protein 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9JLP1
      UniProtKB/TrEMBL
      A6HRU0, F1LMN8
      Related
      ENSRNOP00000012753.8, ENSRNOT00000012753.9
      Conserved Domains (3) summary
      pfam16274
      Location:453
      Qua1; Qua1 domain
      pfam16568
      Location:266320
      Sam68-YY; Tyrosine-rich domain of Sam68
      cd22470
      Location:48160
      KH-I_KHDRBS3; type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      102726628..102884545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264204.1XP_063120274.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X3

      UniProtKB/Swiss-Prot
      Q9JLP1
      UniProtKB/TrEMBL
      A0A8I5YBJ1
      Related
      ENSRNOP00000076402.1, ENSRNOT00000112404.2
    2. XM_063264202.1XP_063120272.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9JLP1
    3. XM_063264203.1XP_063120273.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q9JLP1

    RNA

    1. XR_005486718.2 RNA Sequence

      Related
      ENSRNOT00000097337.2
    2. XR_010053039.1 RNA Sequence

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