Epha7 Eph receptor A7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epha7provided by RGD
Official Full Name: Eph receptor A7provided by RGD
Primary source: RGD:70957
See related: EnsemblRapid:ENSRNOG00000007030 AllianceGenome:RGD:70957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EHK-3
Summary: Enables ephrin receptor binding activity and protein tyrosine kinase activity. Involved in phosphorylation and positive regulation of apoptotic process. Located in dendrite; neuronal cell body; and postsynaptic membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Orthologous to human EPHA7 (EPH receptor A7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 66.7), Kidney (RPKM 31.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (47771776..47925189)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (42975353..43128703)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (43602744..43761198)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Erythropoietin-producing hepatocellular receptor A7 restrains estrogen negative feedback of luteinizing hormone via ephrin A5 in the hypothalamus of female rats.
Title: Erythropoietin-producing hepatocellular receptor A7 restrains estrogen negative feedback of luteinizing hormone via ephrin A5 in the hypothalamus of female rats.
EPHA7 is a positive upstream factor of C/EBPbeta contributing to the transcription and translation of KLF4, promoting ovulation via ADAMTS1. We demonstrated the functional role of EPHA7 in PCOS, which explains how the loss of EPHA7 underlies the ovulatory dysfunction.
Title: Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndrome.
EphA7 regulates gephyrin clustering and the maintenance of inhibitory synaptic connectivity via mTOR signaling.
Title: Receptor tyrosine kinase EphA7 is required for interneuron connectivity at specific subcellular compartments of granule cells.
The cell surface localization of EphA7 was preferentially in postsynaptic dendrites in the hippocampus and cerebellum.
Title: Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat.
This study demonistrated that EphA7 expression identifies a novel "matrisome" compartment within the matrix that binds ephrin-A5 and possesses unique axonal projections.
Title: EphA7 expression identifies a unique neuronal compartment in the rat striatum.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Epha7 (e-PCR), detects polymorphism
- UniSTS:495885

UniSTS:224539 (e-PCR)
- UniSTS:224539

RH143595 (e-PCR)
- UniSTS:232841

UniSTS:266990 (e-PCR)
- UniSTS:266990

Epha7 (e-PCR), detects polymorphism
- UniSTS:266990

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables GPI-linked ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables axon guidance receptor activity	IEA Inferred from Electronic Annotation more info
enables axon guidance receptor activity	ISO Inferred from Sequence Orthology more info
enables axon guidance receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables chemorepellent activity	IEA Inferred from Electronic Annotation more info
enables chemorepellent activity	ISO Inferred from Sequence Orthology more info
enables chemorepellent activity	ISS Inferred from Sequence or Structural Similarity more info
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables ephrin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in branching morphogenesis of a nerve	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching morphogenesis of a nerve	ISO Inferred from Sequence Orthology more info
involved_in branching morphogenesis of a nerve	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in nephric duct morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nephric duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal ganglion cell axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ephrin type-A receptor 7

Names: EPH homology kinase 3; ephrin receptor EphA7; tyrosine-protein kinase receptor EHK-3

NP_599158.1

EC 2.7.10.1

XP_006238024.1

EC 2.7.10.1

XP_006238025.1

EC 2.7.10.1

XP_006238026.1

EC 2.7.10.1

XP_006238027.1

EC 2.7.10.1

XP_038965152.1

EC 2.7.10.1

XP_038965153.1

EC 2.7.10.1

XP_038965154.1

EC 2.7.10.1

XP_063143188.1

EC 2.7.10.1

XP_063143189.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134331.2 → NP_599158.1 ephrin type-A receptor 7 precursor

See identical proteins and their annotated locations for NP_599158.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P54759

UniProtKB/TrEMBL

A6III2

Related

ENSRNOP00000009899.4, ENSRNOT00000009899.7

Conserved Domains (5) summary

cd09548
Location:919 → 988

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:628 → 894

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:565 → 630

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

47771776..47925189

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237964.5 → XP_006238026.1 ephrin type-A receptor 7 isoform X6

See identical proteins and their annotated locations for XP_006238026.1

UniProtKB/TrEMBL

A0A8I5ZVN2, A6III3

Conserved Domains (4) summary

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:333 → 427

fn3; Fibronectin type III domain

pfam07699
Location:275 → 312

Ephrin_rec_like; Putative ephrin-receptor like
XM_006237962.5 → XP_006238024.1 ephrin type-A receptor 7 isoform X1

UniProtKB/TrEMBL

A0A8L2Q443

Conserved Domains (5) summary

cd09548
Location:915 → 984

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:624 → 890

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:565 → 626

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_063287118.1 → XP_063143188.1 ephrin type-A receptor 7 isoform X4
XM_006237963.5 → XP_006238025.1 ephrin type-A receptor 7 isoform X2

Conserved Domains (5) summary

cd09548
Location:914 → 983

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:623 → 889

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:560 → 625

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_039109224.2 → XP_038965152.1 ephrin type-A receptor 7 isoform X3

Conserved Domains (5) summary

cd09548
Location:910 → 979

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:619 → 885

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:560 → 621

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_006237965.5 → XP_006238027.1 ephrin type-A receptor 7 isoform X9

See identical proteins and their annotated locations for XP_006238027.1

UniProtKB/TrEMBL

A6III1

Conserved Domains (4) summary

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:333 → 427

fn3; Fibronectin type III domain

cl22855
Location:263 → 317

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_063287119.1 → XP_063143189.1 ephrin type-A receptor 7 isoform X8
XM_039109226.2 → XP_038965154.1 ephrin type-A receptor 7 isoform X7

Related

ENSRNOP00000082816.2, ENSRNOT00000102430.2

Conserved Domains (4) summary

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:333 → 427

fn3; Fibronectin type III domain

pfam07699
Location:275 → 312

Ephrin_rec_like; Putative ephrin-receptor like
XM_039109225.2 → XP_038965153.1 ephrin type-A receptor 7 isoform X5

Conserved Domains (5) summary

cd09548
Location:843 → 912

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd00063
Location:367 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:552 → 818

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:489 → 554

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 130

EphR_LBD; Ligand Binding Domain of Ephrin Receptors