Gstp1 glutathione S-transferase pi 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gstp1provided by RGD
Official Full Name: glutathione S-transferase pi 1provided by RGD
Primary source: RGD:2758
See related: EnsemblRapid:ENSRNOG00000018237 AllianceGenome:RGD:2758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gst3; Gstp; GST-P; Gstp2
Summary: Enables organic cyclic compound binding activity; protein kinase binding activity; and toxic substance binding activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to epidermal growth factor stimulus; and negative regulation of smooth muscle cell chemotaxis. Predicted to be located in mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Biomarker of cholestasis; pre-malignant neoplasm; prostate carcinoma in situ; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1432.6), Lung (RPKM 923.0) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (210767237..210770242, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (201337762..201340230, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (219291679..219294147, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4.
Title: Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4.
The cytotoxic action of 2-acetylaminofluorene that give rise to the GST-P(+) single hepatocytes was suggested to be an injury to the excretory pump(s) and the duct of hepatocytes. A new physiological mechanism was hypothesized for the induction of preneoplastic cell populations in the rat liver instead of a genetic mechanism.
Title: Strong carcinogenic stress response induction of preneoplastic cells positive for GST-P in the rat liver: Physiological mechanism for initiation.
Data suggest that expression of Gstp1 can be regulated by dietary factors; here, Gstp1 is induced in hepatocytes by carnosic acid, an anticarcinogenic component of rosemary (Rosmarinus officinalis).
Title: Induction of the pi class of glutathione S-transferase by carnosic acid in rat Clone 9 cells via the p38/Nrf2 pathway.
Data show that Valerian extract inhibits hepatocarcinogenesis by suppressing cell proliferation and inducing apoptosis in glutathione S-transferase pi GST-P(+) foci by activating gamma-aminobutyric acid A receptor GABA(A)RA1-mediated signaling.
Title: Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.
Cisplatin metabolism in different organs of rats correlated positively with specific GSTP1 activities and this enzyme may be a critical determinant of extent of cellular uptake or retention of cisplatin in renal and liver tissues.
Title: Metabolism of cisplatin in the organs of Rattus norvegicus: role of Glutathione S-transferase P1.
The influence of dietary lipids on the ontogeny of XMEs was also evaluated. mRNA and protein levels of phase I (CYP1A1, CYP1A2, and CYP1B1) and phase II (NAD(P)H:quinone acceptor oxidoreductase 1 and GSTP1) enzymes were analyzed.
Title: Ontogeny of the major xenobiotic-metabolizing enzymes expression and the dietary lipids modulatory effect in the rat dimethylbenz(a)anthracene-induced breast cancer model.
GSTP1 application early after myocardial infarction results in long-term beneficial structural and functional effects that prevent progression to heart faiilure.
Title: Single-dose GSTP1 prevents infarction-induced heart failure.
GST-P(-) foci induced by promotion with agonists of peroxisome proliferator-activated receptor-alpha.
Title: Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model.
GSTpi directly associated with signal transducer and activator of transcription 3 (STAT3) to prevent Angiotensin II-triggered binding of Src to STAT3.
Title: GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation.
The change in expression of GST-pi in peripheral blood showed the same pattern as that in brain tissues, suggesting GST-pi might contribute to drug resistance in epilepsy.
Title: Correlation study on expression of GST-π protein in brain tissue and peripheral blood of epilepsy rats induced by pilocarpine.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Wox36 (e-PCR)
- UniSTS:118102

RH137035 (e-PCR)
- UniSTS:219124

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables S-nitrosoglutathione binding	ISO Inferred from Sequence Orthology more info
enables dinitrosyl-iron complex binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables toxic substance binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cell-matrix adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in common myeloid progenitor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione derivative biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione derivative biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of leukocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotactic protein-1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of TRAF2-GSTP1 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutathione S-transferase P

Names: GST 7-7; GST class-pi; Glutathione-S-transferase, placental enzyme pi type; chain 7; glutathione S-transferase, pi 2

NP_036709.1

EC 2.5.1.18

XP_063136797.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012577.2 → NP_036709.1 glutathione S-transferase P

See identical proteins and their annotated locations for NP_036709.1

Status: VALIDATED

Source sequence(s)

BC058440, JAXUCZ010000001

UniProtKB/Swiss-Prot

P04906

UniProtKB/TrEMBL

A6HYR6, B6DYQ7

Related

ENSRNOP00000024601.4, ENSRNOT00000024601.6

Conserved Domains (2) summary

cd03210
Location:84 → 210

GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases

cd03076
Location:3 → 76

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...