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    Mast2 microtubule associated serine/threonine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313819, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mast2provided by RGD
    Official Full Name
    microtubule associated serine/threonine kinase 2provided by RGD
    Primary source
    RGD:1304573
    See related
    EnsemblRapid:ENSRNOG00000058476 AllianceGenome:RGD:1304573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and microtubule binding activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAST2 (microtubule associated serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 117.8), Muscle (RPKM 101.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mast2 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135013006..135152195, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129776293..129915502, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135149336..135285337, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103122 Neighboring gene transfer RNA proline (anticodon AGG) 7 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L7a, pseudogene 20 Neighboring gene intracisternal A particle-promoted polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding  
    enables microtubule binding  
    enables microtubule binding  
    enables phosphatase binding  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in cytoskeleton organization  
    involved_in intracellular signal transduction  
    involved_in protein phosphorylation  
    involved_in regulation of interleukin-12 production  
    involved_in spermatid differentiation  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  

    General protein information

    Preferred Names
    microtubule-associated serine/threonine-protein kinase 2
    NP_001101475.2
    XP_006238736.2
    XP_006238737.2
    XP_017448928.2
    XP_017448930.1
    XP_038966059.1
    XP_038966060.1
    XP_038966061.1
    XP_038966062.1
    XP_063143915.1
    XP_063143916.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108005.3NP_001101475.2  microtubule-associated serine/threonine-protein kinase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZMP0, A6JZ72

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135013006..135152195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238675.5XP_006238737.2  microtubule-associated serine/threonine-protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A6JZ72
      Related
      ENSRNOP00000079306.2, ENSRNOT00000114619.2
      Conserved Domains (3) summary
      cd00992
      Location:11021183
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:512791
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202476
      DUF1908; Domain of unknown function (DUF1908)
    2. XM_006238674.5XP_006238736.2  microtubule-associated serine/threonine-protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A6JZ72
      Related
      ENSRNOP00000097145.2, ENSRNOT00000102929.2
      Conserved Domains (3) summary
      cd00992
      Location:11091190
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:519798
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202483
      DUF1908; Domain of unknown function (DUF1908)
    3. XM_017593439.3XP_017448928.2  microtubule-associated serine/threonine-protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATY6, A6JZ72
      Conserved Domains (3) summary
      cd00992
      Location:11091190
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:519798
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202483
      DUF1908; Domain of unknown function (DUF1908)
    4. XM_063287846.1XP_063143916.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

      UniProtKB/TrEMBL
      D3ZAR2
    5. XM_017593441.3XP_017448930.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

      UniProtKB/TrEMBL
      D3ZAR2
    6. XM_063287845.1XP_063143915.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

      UniProtKB/TrEMBL
      D3ZAR2
    7. XM_039110131.2XP_038966059.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZUU6, D3ZAR2
      Related
      ENSRNOP00000081749.2, ENSRNOT00000096569.2
      Conserved Domains (3) summary
      cd00992
      Location:10231104
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:433712
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:116397
      DUF1908; Domain of unknown function (DUF1908)
    8. XM_039110132.2XP_038966060.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      D3ZAR2
      Related
      ENSRNOP00000086302.2, ENSRNOT00000104664.2
      Conserved Domains (3) summary
      cd00992
      Location:9581039
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:368647
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:51332
      DUF1908; Domain of unknown function (DUF1908)
    9. XM_039110133.2XP_038966061.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

      UniProtKB/TrEMBL
      D3ZAR2
      Conserved Domains (3) summary
      cd00992
      Location:9321013
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:342621
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:25306
      DUF1908; Domain of unknown function (DUF1908)
    10. XM_039110134.2XP_038966062.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

      UniProtKB/TrEMBL
      D3ZAR2
      Conserved Domains (3) summary
      cd00992
      Location:9251006
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:335614
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:25299
      DUF1908; Domain of unknown function (DUF1908)
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