Gcc2 GRIP and coiled-coil domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gcc2provided by RGD
Official Full Name: GRIP and coiled-coil domain containing 2provided by RGD
Primary source: RGD:1305732
See related: EnsemblRapid:ENSRNOG00000000823 AllianceGenome:RGD:1305732
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to organelle; and retrograde transport, endosome to Golgi. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 96.5), Brain (RPKM 88.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (26788472..26836728)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (26247394..26293613)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (27832960..27879764)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in late endosome to Golgi transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in late endosome to Golgi transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule organizing center organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule organizing center organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to lysosome	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in recycling endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in recycling endosome to Golgi transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein exit from endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein exit from endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GRIP and coiled-coil domain-containing protein 2

Names: 185 kDa Golgi coiled-coil protein; LIM and senescent cell antigen-like domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107633.2 → NP_001101103.1 GRIP and coiled-coil domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_001101103.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

D3ZZL9

Conserved Domains (5) summary

COG1196
Location:462 → 1243

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:26 → 830

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam01465
Location:1609 → 1651

GRIP; GRIP domain

pfam07851
Location:106 → 203

TMPIT; TMPIT-like protein

pfam16704
Location:1543 → 1607

Rab_bind; Rab binding domain
NM_001434628.1 → NP_001421557.1 GRIP and coiled-coil domain-containing protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A0H2UH94

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

26788472..26836728

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256375.5 → XP_006256437.1 GRIP and coiled-coil domain-containing protein 2 isoform X1

Related

ENSRNOP00000001092.4, ENSRNOT00000001092.6

Conserved Domains (5) summary

COG1196
Location:464 → 1245

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:28 → 832

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam01465
Location:1611 → 1653

GRIP; GRIP domain

pfam07851
Location:108 → 205

TMPIT; TMPIT-like protein

pfam16704
Location:1545 → 1609

Rab_bind; Rab binding domain
XM_039098762.2 → XP_038954690.1 GRIP and coiled-coil domain-containing protein 2 isoform X2

Conserved Domains (2) summary

COG1196
Location:464 → 1245

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:78 → 759

SMC_prok_B; chromosome segregation protein SMC, common bacterial type