Serpinb11 serpin family B member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpinb11provided by RGD
Official Full Name: serpin family B member 11provided by RGD
Primary source: RGD:1306497
See related: EnsemblRapid:ENSRNOG00000002583 AllianceGenome:RGD:1306497
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Orthologous to human SERPINB11 (serpin family B member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 32.4), Lung (RPKM 14.4) and 3 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (23819416..23859240)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (23304775..23344604)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (27217385..27257181)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: serpin B11

Names: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11; serpin peptidase inhibitor, clade B (ovalbumin), member 11; serpin peptidase inhibitor, clade B, member 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107167.1 → NP_001100637.1 serpin B11

See identical proteins and their annotated locations for NP_001100637.1

Status: PROVISIONAL

Source sequence(s)

CH474000

UniProtKB/TrEMBL

A6JSV7, D3ZJI7

Related

ENSRNOP00000003495.4, ENSRNOT00000003495.7

Conserved Domains (1) summary

cd19570
Location:1 → 388

serpinB11_epipin; serpin family B member 11, epipin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

23819416..23859240

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249633.4 → XP_006249695.2 serpin B11 isoform X2

UniProtKB/TrEMBL

A0A8I5ZXG7

Related

ENSRNOP00000084176.1, ENSRNOT00000116267.2

Conserved Domains (1) summary

cl00137
Location:36 → 420

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
XM_006249632.5 → XP_006249694.3 serpin B11 isoform X1
XM_017598781.3 → XP_017454270.1 serpin B11 isoform X3

Conserved Domains (1) summary

cl00137
Location:1 → 216

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
XM_008769453.3 → XP_008767675.1 serpin B11 isoform X3

Conserved Domains (1) summary

cl00137
Location:1 → 216

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...