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    Rnf182 ring finger protein 182 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf182provided by RGD
    Official Full Name
    ring finger protein 182provided by RGD
    Primary source
    RGD:1560399
    See related
    EnsemblRapid:ENSRNOG00000018070 AllianceGenome:RGD:1560399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560399
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human RNF182 (ring finger protein 182). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 40.7), Kidney (RPKM 10.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf182 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (21232084..21287329, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (21026110..21081760, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (24242640..24292975)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097907 Neighboring gene uncharacterized LOC134482702 Neighboring gene solute carrier family 25 member 31, pseudogene 1 Neighboring gene uncharacterized LOC134482833 Neighboring gene mitochondrial calcium uniporter regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation. Liu QY, et al. Mol Neurodegener, 2008 Feb 25. PMID 18298843, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF182
    Names
    RING-type E3 ubiquitin transferase RNF182
    NP_001102587.1
    XP_017456133.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109117.3 → NP_001102587.1  E3 ubiquitin-protein ligase RNF182

      See identical proteins and their annotated locations for NP_001102587.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      D3ZBM4
      Related
      ENSRNOP00000102720.1, ENSRNOT00000146841.1
      Conserved Domains (1) summary
      smart00184
      Location:20 → 67
      RING; Ring finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      21232084..21287329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600644.3 → XP_017456133.1  E3 ubiquitin-protein ligase RNF182 isoform X1

      UniProtKB/Swiss-Prot
      D3ZBM4
      Related
      ENSRNOP00000024323.2, ENSRNOT00000024323.5
      Conserved Domains (1) summary
      smart00184
      Location:20 → 67
      RING; Ring finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZBM4.1 GenPept UniProtKB/Swiss-Prot:D3ZBM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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