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    St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25280, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St8sia1provided by RGD
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by RGD
    Primary source
    RGD:3679
    See related
    EnsemblRapid:ENSRNOG00000014018 AllianceGenome:RGD:3679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat8; Siat8a
    Summary
    Enables sialyltransferase activity. Predicted to be involved in N-glycan processing; oligosaccharide metabolic process; and protein glycosylation. Predicted to act upstream of or within cellular response to heat and positive regulation of epithelial cell proliferation. Predicted to be located in Golgi membrane. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 318.1), Brain (RPKM 55.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See St8sia1 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177513966..177651553, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175782989..175921338, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (177065266..177195942, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cytidine monophosphate N-acetylneuraminic acid synthetase Neighboring gene sulfotransferase family 6B, member 2 Neighboring gene uncharacterized LOC134486862 Neighboring gene C2 calcium-dependent domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons. Copani A, et al. J Neurosci, 2002 May 15. PMID 12019315, Free PMC Article
    2. The molecular cloning and expression of alpha 2,8-sialyltransferase (GD3 synthase) in a rat brain. Watanabe Y, et al. J Biochem, 1996 Nov. PMID 8982871
    3. Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility. Kamimura Y, et al. Int J Oncol, 2005 Feb. PMID 15645117
    4. Molecular cloning of cDNA for rat brain GD3-synthase. Zeng G, et al. Biochem Biophys Res Commun, 1996 Sep 13. PMID 8806633
    5. GD3 synthase gene found expressed in dental epithelium and shown to regulate cell proliferation. Yamada A, et al. Arch Oral Biol, 2005 Apr. PMID 15748692

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alpha2,8-sialyltransferase has roles in cell proliferation and mobility
      Title: Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
    Names
    GD3 synthase
    ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1
    Sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase)
    Sialyltransferase 8 A (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase) GenBank no: U53883
    alpha-2, 8-sialytransferase
    alpha-2,8-sialyltransferase
    alpha-N-acetylneuraminate: alpha-2,8-sialytransferase
    sialyltransferase 8 (alpha-2 8-sialytransferase) A
    NP_036945.2
    XP_038963031.1
    XP_038963032.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012813.3 → NP_036945.2  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

      See identical proteins and their annotated locations for NP_036945.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IMW7, G3V7T2, P70554, P97713
      Related
      ENSRNOP00000018999.4, ENSRNOT00000018999.7
      Conserved Domains (1) summary
      pfam00777
      Location:91 → 343
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      177513966..177651553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107103.2 → XP_038963031.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:21 → 201
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_039107104.2 → XP_038963032.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:2 → 196
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version

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